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Articles by F.O. Obi
Total Records ( 4 ) for F.O. Obi
  F.O. Obi , H.C.C. Maduka and Y.P. Mamza
  The effect of treatment with chloroquine and normal saline on blood glucose and serum cholesterol levels was investigated in alloxan-induced diabetic and non-diabetic rabbits. It was observed that high dose of chloroquine (25 mg kg‾1 body wt) administration twice daily for three consecutive days led to an increase in the blood glucose and decrease in the serum cholesterol levels. The possible mechanism for the hyperglycaemic and hypocholesterolemic effects being observed was x-rayed in the light of other reported observations of chloroquine administration.
  A.O. Lawal , A. Ologundudu , F.O. Obi , I.V. Ogungbe , A.O. Olakanye , A.R. Agbetuyi , O.F. Kayode and T. Medale
  The antioxidant effects of aqueous extract of sweet potato (Ipomoea batata) and ascorbic acid on paracetamol induced damage in liver and kidney were investigated in female rats by monitoring the enzymatic and non-enzymatic antioxidant profiles as well as lipid peroxidation and serum enzymes activities. The rats were given freshly prepared aqueous extract of sweet potato (100 mg kg-1 body weight) or ascorbic acid (100 mg kg-1 body weight) orally for 4 weeks. These rats were also given paracetamol (4 g kg-1 body weight) orally for 2 days at the last week of treatment. Another group of rats were either given extract (100 mg kg-1 body weight. daily, orally, for 4 weeks) or ascorbic acid (100 mg kg-1 body weight. daily, orally, for 4 weeks) or paracetamol (4 g kg-1 body weight for 2 days) or distilled water. The results show that the level of lipid peroxides in the liver and kidney and serum enzymes GOT and GPT activities were significantly decreased in extract and ascorbic acid pretreated rats when compared to control (p<0.05). Paracetamol however significantly increase the level of these parameters when compared to control. Liver and kidney Superoxide Dismutase (SOD) and Catalase activities significantly increase in extract and ascorbic acid pretreated rats compared to control. Paracetamol significantly reduced the activities of these enzymes in liver but the reduction in SOD activity was not significant in the kidney when compared to control. There were significant increase in reduced Glutathione (GSH) in both organs in ascorbic acid pretreated rat but the increase were not significant in extract pretreated rats. Paracetamol significantly decrease GSH level in the liver when compared to control. The study revealed that sweet potato extract and ascorbic acid have a potential to prevent oxidative damage induced by acute dose of paracetamol in both the liver and the kidney.
  G.E. Eriyamremu , M.A. Adaikpoh and F.O. Obi
  Cell membrane composition and fluidity are altered in diseases and previous reports suggest that membrane lipid is altered in heavy metal toxicity. This study was carried out to assess the effect of cadmium alone and its combination with different doses (75, 150 and 750 mg) of α-tocophenylacetate on the phospholipid profile and alkaline phosphatase activity in the kidney and liver of rats. The results obtained show that in these tissues, cadmium significantly (p<0.05) increased the levels of protein compared with the control, in the liver it significantly raised total lipid levels and decreased it in the kidney. Vitamin E in the form of α-tocophenylacetate reversed these observations. Cadmium decreased alkaline phosphatase activity significantly (p<0.05) in both tissues; a trend that was counteracted by α-tocophenylacetate supplementation in a dose dependent pattern. In both the liver and kidney, cadmium treatment reduced the levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and increased sphingomyelin (SGM). It raised the PC/PE and SGM/PC ratios, index of membrane fluidity. Vitamin E supplementation significantly reduced the SGM/PC ratios in a manner that appears to be dose related. In the liver the effect of the vitamin on the SGM/PC ratio range from about 400 to 300 to 800% in the 75, 150 and 750 mg supplemented groups, respectively. A similar trend was also observed in the kidney. We hypothesize that decreased membrane fluidity occasioned by increase in SGM/PC ratio occur in early cadmium toxicity and that vitamin E cushions the effect of cadmium by decreasing SGM/PC ratio.
  A. Ologundudu and F.O. Obi
  The effects of orally administered decoction of the dried flower of Hibiscus sabdariffa on 2, 4-dinitrophenylhydrazine-induced lipid peroxidation and reduced glucose concentration in blood, brain and liver have been examined in rabbits. Following oral administration of the decoction (200 mg kg-1 body wt.) once/day for 3 days, 2, 4-dinitrophenylhydrazine (2, 4-DNPH) was administered in saline (28 mg kg-1 body wt.) intraperitoneally. Three hours after 2, 4-DNPH administration the rabbits were sacrificed. The results show that treatment with 2, 4-DNPH alone significantly (p<0.05) reduced brain glucose when compared with the control (control 0.23±0.02 mM; 2, 4-DNPH treated: 0.12±0.03 mM). Treatment with the decoction before 2, 4-DNPH caused significant (p<0.05) increase in brain glucose relative to that of the group treated with 2, 4-DNPH alone (DNPH alone-0.12±0.03 mM; Decoction + DNPH-0.18±0.01 mM): Exposure of rabbits to 2, 4-DNPH produced significant (p<0.05) increase in lipoperoxidation in blood (28.20±4.19 units/mL x 10-7) brain (21.30±4.28 units/mL x 10-7) and liver (36.97±2.72 units/mL x 10-7) as indicated by malondialdehyde level when compared to the control (blood: 1.54±0.22; brain: 5.25±0.56; liver: 7.50±2.67 units/mL x 10-7). In rabbits treated with the decoction prior to DNPH the level of malondialdehyde was significantly (p<0.05) decreased in the blood (6.73±0.55 units/mL x 10-7) brain (6.93±0.20 units/mL x 10-7) and liver (9.37±2.14 units/mLx10-7) relative to the group treated with DNPH alone. The data obtained in this study show that the decoction of the dried flower of H. sabdariffa was able to prevent not only 2, 4-DNPH-induced decrease in brain glucose but also its lipoperoxidative effect in the blood, brain and liver in the rabbit.
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