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Articles by F.J. AL-Saffar
Total Records ( 7 ) for F.J. AL-Saffar
  F.J. Al-Saffar
  Goat’s industry becomes very attractive in various countries and play a vital role in socio-economic organization. A different diet causes different effects in the animal performance. Therefore, this study was intended to detect the effect of different diets on the number and distribution of endocrine Gastrin (G) cells in the goat’s abomasum. Twenty four, 9 months aged local goats were equally divided into control and two treatment groups. The control group was fed a diet consisting of 60% guinea grass and 40% concentrates consist of corn, soya bean meal, calcium, minerals, vitamins and 12.8% crude protein. The first treatment group was fed with 10% guinea grass and 90% palm kernel cake consist of calcium, minerals, vitamins and 15.2% crude protein. The second treatment group was fed with a diet similar to those of the first treatment group but with addition of molybdenum 40 ppm and sulphur 100 ppm. Goats in each group were fed daily with the selected diet for 120 days and then slaughtered and their abdomens were dissected and the abomasums were removed and processed for both histological and immunohistochemistry standard procedures. Microscopic findings revealed that treated groups that fed with high protein diet showed significantly (p<0.05) higher number of G cells than those of the control goats. Fluorescein isothiocyanate technique showed G cells distributed only in the pyloric mucosa of the abomasum with specific pattern of distribution. Current data concluded that G cells density in the pyloric mucosa have different responses to the different supplemented diets.
  F.J. Al-Saffar and Eyhab R.M. Al-Samawy
  The study aimed to find out the histomorphological and histochemical structures of the walls of the stomach parts in mallard. To conduct this investigation, twelve healthy birds were collected from local suppliers at Baghdad province. Later on, birds were subdivided into three equal subdivisions, each of four for gross, histological and histochemical approaches. All birds were anesthetized and their abdomens were dissected, then their stomach were identified and photographed in situ. Organs were grossly described and specimens were immersed either in 10% neutral buffered formalin or in Bouin’s solution for histological fixation and then processed for histological and histochemical staining techniques, which were comprised Hematoxylin-eosin, Masson Trichrome, Periodic Acid Schiff (PAS) and PAS-Alcian Blue (AB) (pH 2.5). The gross findings showed that the stomach was consisted of two distinguishable chambers, that were proventriculus and ventriculus. The proventriculus was tubular-shaped organ. The ventriculus appeared fusiform in shape and covered by thin fatty tissue. There was well demarcation between proventriculus and ventriculus. Histologically, the proventriculus mucosa lining was simple columnar epithelium. The submucosal consists of numerous and voluminous deep submucosal glands. The covering of the ventriculus was simple cuboidal. Presence of thick cuticle layer with well-developed muscular stomach. Muscularis mucosa appeared characteristically thick layer of smooth muscle bundles arranged as, inner circular and outer longitudinal layers. The tunica muscularis appeared, as a very thick structure of smooth muscles fibers. Three layers of muscles were distinguished that were thin inner, outer longitudinal and very thick intermediate circular layers.
  F.J. AL-Saffar , S. Ganabadi , H. Yaakub and S. Fakurazi
  The objective of this study was to apply and compare two different experimental osteoarthritis (OA) methods in the rat, namely: Collagenase induced OA (CO) and Monosodium iodoacetate induced OA (MIA) models. The assessment of OA development and progression were performed through three different periods (2, 4 and 6 weeks). Intra-articular injection of either 4 mg joint-1 CO type II or 3 mg joint-1 MIA, were administered to the adult male Sprague Dawley rats, into their right knee joints. Evaluation of OA changes in the knees was achieved with both histopathology score system and radiography approach. Gross results revealed earliest changes such as swelling and redness of the right knee joints of all rats injected with either CO or MIA. Joint dissection revealed distinct thickening of the joint capsule in MIA-injected rats than in CO group. Present finding revealed early development of radiographical as well as histopathological changes in MIA injected group. However, both OA injected groups resulted in a chronic joint degeneration, measured by cellular changes, matrix degradation, subchondral changes and marginal osteophyte formation. Present findings showed significantly higher histopathological score in MIA injected group than those of CO in each of the three selected periods for OA induction. In conclusion, present results demonstrated that MIA can induce OA changes in a shorter period of time than CO in the Sprague Dawley rat. Radiography approach could be a useful tool to evaluate osteoarthritic changes in the knee joints.
  F.J. Al-Saffar , S. Ganabadi , S. Fakurazi and H. Yaakub
  The main objective of this study was to elucidate the extent of hepatic oxidative stress following oral administration of zerumbone against monosodium iodoacetate induced Osteoarthritis (OA) in rats by monitoring microsomal cytochrome P450 and glutathione S-transferase enzymes as well as determination of oxidative stress biomarkers i.e., glutathione and malondialdehyde. Forty rats were randomly assigned into five groups. Rats in the first and second groups were treated with two different doses of zerumbone. Rats in the third group (positive control) were given celecoxib whereas the fourth group (negative control) was given corn oil. Rats of the fifth group were untreated not induced with OA and were used as a basal group. Results showed significant induction of cytochrome P450 and glutathione S-transferase and insignificant changes in both glutathione and lipid peroxidation levels in zerumbone treated groups compared to corn oil and basal groups. Levels of ALT and AST in zerumbone treated groups were comparable to the level in the basal group indicating absence of liver damage. Prostaglandin E2 level significantly reduced following zerumbone administration. Safety profile of zerumbone in this study, attract new investigation to explore its advantageous effect on using higher dosage regimen and/or longer duration against OA or other disease.
  F.J. Al-Saffar , S. Ganabadi and S. Fakuraz
  The main aim of this study was to evaluate oral administration of Channa striatus extract on monosodium iodoacetate induced knee osteoarthritis changes in rat. About 40 rats were randomly assigned to four groups. Rats in the 1st and 2nd groups were treated with the extract in a same dose but with two different courses of therapy. Rats in the 3rd group were treated with celecoxib as a positive control where as the 4th group was treated with normal saline as a negative control. Evaluation of osteoarthritis changes was assessed with the aid of radiology, histopathology score and immunohistochemistry to explore immunoreactivity in the synovium. Assay of prostaglandins in the serum had been implemented to explore their role in osteoarthritis events and regulation. Gross and microscopic results revealed curative effects of the extract on the osteoarthritis accompanied with improved immunoreactivity of the synovium. Data showed significant hormonal changes in different treated groups, indicating their role in osteoarthritis. In conclusion, the extract showed inhibitory effect on joint degradation and its earlier therapeutic application reflects importance of earlier treatment on the disease progression. Immunoreactivity as well as serum prostaglandins concentrations could be used as good markers to evaluate osteoarthritis events in the affected joints.
  F.J. Al-Saffar , S. Ganabadi , S. Fakurazi , H. Yaakub and M. Lip
  The objective of this investigation was to evaluate chondroprotective effect of zerumbone, a purified compound of Zingiber zerumbet Smith against monosodium iodoacetate (MIA) induced knee osteoarthritis (OA) in the rat. The effect on the articular cartilage was examined and compared with celecoxib (Celebrex®), a Non-Steroidal Anti-Inflammatory Drug (NSAID). Forty adult male Sprague Dawley rats were divided into four groups (n=10 for each). All animals were injected with MIA intraarticularly in their right knee joints to induce OA. Rats from first and second groups were treated with zerumbone in a same dose but with two different concentrations. Rats in the third group were treated with celecoxib and served as positive control whereas the fourth group were treated with corn oil and served as negative control. Evaluation of OA changes in the knees was assessed with the aid of both radiography and histopathology score. Macroscopic as well as microscopic examinations revealed curative effect of zerumbone in a dose dependent manner on the osteoarthritic knee joints. Apart from this, our data also revealed very poor anti-OA property of celecoxib. We concluded that oral administration of zerumbone in a dose of 2 mL kg-1 b.wt. of 0.4% w/v diluted with corn oil for a period of 4 weeks has some chondroprotective effects.
  F.J. Al-Saffar and A.H.A. Al-Hasnawy
  Current research aimed to investigate the developmental changes of the pancreatic tissues of the local rabbits during different postnatal periods (one, twenty, forty, sixty and eighty days of age). Histological sections prepared from the specimens of their pancreas were stained with general and special stains then photographed with Dino-eye piece camera and analyzed with its image software. Macroscopic examination showed that the pancreas of the rabbit was structured of three lobes that were head, body and tail lobes. The pancreas of rabbit appeared as a diffused type because the lobes were diffusely invested within the mesenteric tissue. The data showed the existence of the accessory pancreatic duct and absence of the major duct. Microscopic findings revealed immature exocrine portion at one day aged rabbits due to the morphological changes established during subsequent ages. The endocrine portion reside primarily in the islet’s of Langerhans which were associated well with extra-blood vessels and exocrine ducts. Microscopically, each islet was structured of several cells (α, β and δ) which were different in size, shape and color. Islets were not fully developed at birth because their densities, cellular content and sizes were changed during different postnatal ages. In conclusion, dramatic critical morphological changes in the exocrine portion at twenty and forty days of age as well as the gradual changes at sixty and eighty days of ages were observed. In addition to that, histological changes in the islet of Langerhans such as their densities, sizes and cellular content indicated their immaturity at birth.
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