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Articles by F.E. Uboh
Total Records ( 8 ) for F.E. Uboh
  F.E. Uboh , E.N. Asuquo , M.U. Eteng and E.O. Akpanyung
  Endosulfan is known to be one of the highly toxic agricultural pesticides commonly used in our societies. With the widespread use of endosulfan in agriculture, human beings are most likely to be exposed to it, either orally by eating endosulfan-contaminated foods or by nose and whole body inhalation in the farms during its application. In this study, we assessed the route-of-exposure-dependent effect of endosulfan on renal functions in male rats, using serum creatinine, urea, Blood Urea Nitrogen (BUN), uric acid, Na+, Cl¯ and K+, as well as histopathological assay. Eighteen mature male albino Wistar rats (200±20 g), divided into three groups of six rats each, were used in this study. The 20 mg kg-1 body weight of endosulfan was daily administered orally to one group of rats while another group was exposed to ungraded concentration of endosulfan by nose and whole body inhalation exposure method, (4 h daily, 6 days per week), for 30 days. It was observed from the results of this study that exposure to endosulfan by both oral and inhalation routes produced a significant increase (p<0.05) in serum creatinine, urea, BUN, uric acid and K+ and a significant decrease (p<0.05) in serum Na+ and Cl¯ levels, compared, respectively to the control. Also, microscopic examinations showed that both routes of exposure to endosulfan exhibited severe a histopathological damage to the renal tissues. These observations indicated that exposure to endosulfan may be a risk factor for nephrotoxicity in rats, independent of the route of exposure.
  F.E. Uboh , M.I. Akpanabiatu , I.J. Atangwho , P.E. Ebong and I.B. Umoh
  The effect of vitamin A on weight-loss, growth-depression and haematotoxicity associated with gasoline vapours exposure was assessed in male and female Wistar albino rats. The rats were exposed to ungraded concentrations of gasoline vapours (6 h daily) for 20 weeks. Vitamin A (retinol) at prophylactic dosage (400 IU kg-1 day-1) was orally administered to the rats in the last two weeks of exposure. The levels of haemoglobin (Hb), haematocrit or Packed Cell Volume (PCV), Red Blood Cells (RBC), weight gain and growth rate in the male and female rats exposed to the vapours were significantly lower (p<0.05) compared respectively to the levels obtained for male and female control rats. On the other hand, the levels of White Blood Cells (WBC) in the male and female test rats were significantly higher (p<0.05) compared respectively with the level obtained for male and female control rats. These observations indicated that exposure to gasoline vapours produced haematotoxicity, weight loss and growth depression in rats. However, administration of vitamin A was observed to produce a significant regain (p<0.05) in weight-loss, growth-depression and haematotoxicity observed to be associated with exposure to gasoline vapours, although the females were noted to respond more favourably than the males. This suggests that vitamin A may be used to reverse or prevent weight-loss, growth-depression and haematotoxicity in subjects exposed to gasoline vapours.
  F.E. Uboh , M.I. Akpanabiatu , Y. Alozie , E.E. Edet , J.I. Ndem and P.E. Ebong
  Comparative effect of vitamins A and E on gasoline vapours haematotoxicity, growth-depression and weight-loss was assessed in male Wistar albino rats. The rats were exposed to gasoline vapours (17.8±2.6 cm3/h/m3/day), 6 h/day, 6 days/week for 20 weeks. Vitamins A (retinol) and E(α-tocopherol) at prophylactic dosage (400 and 200 IU/kg/day, respectively) were orally administered to the rats separately, in the last 2 weeks of exposure. The levels of haemoglobin (Hb), haematocrit or Packed Cell Volume (PCV), Red Blood Cells (RBC), growth-rate and weight-gain in the rats exposed to the vapours were significantly lower (p<0.05) compared, respectively to the levels obtained for control rats. On the other hand, the levels of White Blood Cells (WBC) in the test rats were significantly higher (p<0.05) compared, respectively with the level obtained for male control rats. These observations indicate that exposure to gasoline vapours may cause haematotoxicity, growth-depression and weight-loss in male rats. However, administration of vitamins A and E was observed to produce a significant recovery (p<0.05) in haematotoxicity, growth-depression and weight-loss observed to be associated with exposure to gasoline vapours, although, the rats administered with vitamin E were noted to respond more favourably than those administered with vitamin A. This suggests that although retinol and α-tocopherol may be used to reverse or prevent haematotoxicity, growth-depression and weight-loss in subjects exposed to gasoline vapours, the reversal potency of α-tocopherol is higher than that of retinol.
  F.E. Uboh , M.I. Akpanabiatu and Y. Alozie
  The effect of gasoline vapours (17.8±2.6 cm3/h/m3/day) on renal functions was assessed from the total kidney weights and the levels of serum creatinine, urea and blood urea nitrogen (BUN) in male and female rats, following 64 days of exposure. The results showed an insignificant (p>0.05) increase in percentage kidney weight per total body weight (PKW/BW), decrease in total serum protein and a significant increase (p<0.05) in serum creatinine, urea and BUN levels in both male and female test rats, compared respectively with the control. However, the percentage changes in the PKW/BW, serum creatinine and urea levels obtained for female rats were observed to be significantly higher (p<0.05), compared to the respective percentage changes obtained for male rats. This observation indicates that frequent exposure to gasoline vapours may cause renal dysfunction in rats, with females at greater risk.
  F.E. Uboh , M.I. Akpanabiatu , I.J. Atangwho and Y. Alozie
  A gender-dependent potential atherosclerotic risk is reported in this study to be associated with exposure to gasoline vapours in rats model. The atherosclerotic risk was assessed from the serum lipid and some electrolytes (Na+, K+ and Cl¯) profiles in male and female rats exposed wholly to 17.8±2.6 cm3/h/kg/m3/day of gasoline vapours (8 h daily, 6 days week-1) for 20 weeks in exposure chambers. A significant increase (p<0.05) in serum total cholesterol (TC), triglycerides (TGs), Low Density Lipoprotein-Cholesterol (LDL-C), Very Low Density Lipoprotein-Cholesterol (VLDL-C), K+ and decrease (p<0.05) in High Density Lipoprotein-Cholesterol (HDL-C), Na+ and Cl- was obtained for both male and female rats exposed to gasoline vapours. These results showed a state of hyperkalaemia, hyponatraemia, increased TG/HDL-C ratio and Atherogenic Index of Plasma (AIP) in male and female rats exposed to gasoline vapours. However, the comparative percentage increase in serum TC, TGs, LDL-C, VLDL-C, K+, as well as percentage decrease in serum HDL-C, Na+ and Cl¯ reported to be associated with exposure to gasoline vapours, were observed to be significantly higher (p<0.05) in females than the male rats. Since hyperlipidaemia, hyperkalaemia and hyponatraemia are known to be implicated in atherosclerosis, the result of this study gives a clear indication that gasoline vapours is among the risk factors for atherosclerosis and that the females are more adversely affected than the males in rats model.
  E.E. Edet , M.I. Akpanabiatu , F.E. Uboh , T.E. Edet , A.E. Eno , E.H. Itam and I.B. Umoh
  The effect of Gongronema latifolium crude leaf extract (GL) on weight-loss, growth-depression and haematotoxicity was assessed in male diabetic rats. Normal and diabetic rats were gavaged with 200, 300 and 400 mg kg-1 b.wt. of GL day-1 for two weeks. The levels of haemoglobin (Hb), haematocrit or Packed Cell Volume (PCV), Red Blood Cells (RBC), white blood cells (WBC) and Platelet Count (PC) in Diabetic Rats (DR) were significantly higher, (p<0.05 for PCV%; p<0.001 for Hb, RBC, WBC and PC), compared, respectively to the levels obtained for the Non-Diabetic Rats (NDR). However, GL at dose levels of 200 and 400 mg kg-1 b.wt., respectively, caused significant decrease in the level of WBC in diabetic treated rats when compared to control. At 300 and 400 mg kg-1 b.wt., PCV% and WBC levels in NDR were significantly different (p<0.05 for both levels at 300 mg kg-1 b.wt.; p<0.05 and p<0.001 for PCV% and WBC at 400 mg kg-1 b.wt.) compared to their controls. The results also showed a significant decrease (p<0.001) in weight and growth-rate of diabetic test groups when compared to non-diabetic test groups following increased treatment with doses of GL. These observations indicated that diabetic condition produces alterations in haematological indices, weight-loss and growth-depression which may be reversed by treatment with GL at 400 mg kg-1 b.wt. in rat model. The significant (p<0.001) increase in WBC counts in alloxan-induced diabetic rats may likely be due to alloxan poisoning, which is in line with the normal physiological response following the perception of an insult to the body defense mechanisms. The results of this study suggest that GL may be used to reverse, prevent or reduce weight-loss, growth-depression and haematotoxicity in diabetic subjects.
  F.E. Uboh , M.I. Akpanabiatu , A.N. Aquaisua and Eno-obong I. Bassey
  Measurement of the levels of total protein, creatinine, uric acid, urea, Blood Urea Nitrogen (BUN), potassium (K+), chloride (Cl-), bicarbonate (HCO3-), sodium (Na+) and calcium (Ca2+) in the blood is useful in assessing the functional integrity of the renal tissues. In this study, the effect of oral exposure to 10, 20 and 30 mg kg-1 b.wt. of nitrocellulose thinner on these serum renal function indices and histopathology of the renal tissues was assessed. Twenty four adult male albino rats (120-150 g), divided into one control and three test groups of six rats each, were used in this study. The rats in the control group were administered with normal saline, while the graded concentrations of the nitrocellulose solvent were each administered orally, as a single daily dosage, for 30 days. The results showed that exposure to nitrocellulose thinner caused a significant (p<0.05) dose-dependent increase in the levels of serum creatinine, uric acid, urea, BUN and K+, as well as decrease in the levels of total serum protein, Cl-, HCO3- and Na+ in rat model. However, there was no significant (p>0.05) difference in serum Ca2+ levels obtained for the rats between and within the test groups, compared to the control. Also, the result of microscopic examinations showed a dose dependent histopathological damage to the renal tissues of rats exposed to nitrocellulose thinner. The observations made from the tissue microscopic analysis, in correlation with that of biochemical assay, indicated the existence of disturbances in the filtration function of the kidneys in rats exposed to higher dosages of the solvent. Hence, the results obtained from our biochemical and histopathogical findings suggested that nitrocellulose thinner possesses the potential (s) of inducing nephrotoxicity in rats.
  F.E. Uboh , Saviour Ufot , Eve Mboso and E.U. Eyong
  This study assessed the effect of oral administration of Costus afer leaves’ juice (CALJ) on the functional integrity of the renal tissues in rats orally exposed to nitrocellulose thinner (NCT). Three groups of six rats each, were orally administered distilled water, NCT (30.0 mg kg-1 b.wt.) and NCT (30.0 mg kg-1 b.wt.) in combination with 600 mg kg-1 b.wt. of CALJ (one hour before NCT administration), respectively for 28 days. The animals were sacrificed after 12 h fast, on the 29th day of the experiment, blood collected through cardiac puncture for serum urea, Blood Urea Nitrogen (BUN), uric acid, creatinine, kidneys for renal tissues malondialdehyde (MDA), Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD) activities determination. The results showed that NCT caused a significant (p<0.05) increase in serum urea, BUN, uric acid, creatinine and renal tissue MDA levels, as well as decrease in renal tissue GPx and SOD activities, compared to control group. These results indicated that NCT’s constituents and their metabolites are nephrotoxic. However, it was observed that administration of CALJ protected the renal tissues against the NCT-induced nephrotoxicity, as indicated by the restoration of serum urea, BUN, uric acid and creatinine levels, as well as renal tissue MDA, GPx and SOD activities to the control range. Also the tubular epithelial necrosis and atrophy of the glomeruli, observed to be associated with exposure to NCT were restored to normal on treatment with CALJ. This study strongly suggested that CALJ’s constituents possess a protective effect against NCT-induced renal tissues damage and reflected the beneficial role of Costus afer in the treatment of various clinical disorders.
 
 
 
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