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Articles by F. Irshaid
Total Records ( 2 ) for F. Irshaid
  F. Irshaid , A. Jaran , F. Dilmi , K. Tarawneh , R. Hadeth and Ahad Al- Khatib
  The aim of this study was to estimate the frequency of EBV infection in Hodgkin’s Lymphoma (HL) and Non-Hodgkin’s Lymphoma (NHL) occurring in Jordanian patients. A total of 55 patients with lymphoma were examined. The diagnosis was confirmed by staining the slides of these cases with hematoxylin and eosin. The presence of EBV was detected by immunostating for expression of latent membrane protein-1 (LMP-1). Of 55 patients, 31 and 25 were diagnosed as HL and NHL, respectively. The majority of the HL cases exhibited Mixed Cellularity (MC) subtype. The high grade was found to be the commonest subtype of NHL. The frequency of LMP-1 expression occurred more frequent in patients with HL (60.0%) than in patients with NHL (32.0%). The frequency of LMP-1 expression was higher in patients with MC subtype (61.11%) than in patients with nodular sclerosis (28.57%). No age or gender difference in occurrence of EBV infection was observed among HL patients. By contrast, the frequency of LMP-1 expression in NHL patients aged below 50 was lower (16.66%) than in NHL patients aged 50 or above (46.15%). In addition, EBV infection was more frequent in females with NHL (38.46%) than in male with NHL (25%). In NHL cases, the frequency of LMP-1 expression in intermediate grade (60.0%) was high compared to low (37.5%) or high grades (16.7%). Therefore, analysis of LMP-1 expression suggests an important role for this viral oncogene in the pathogenesis of EBV-associated malignant lymphomas. These data support the previous findings that people with EBV may develop lymphoma and that efforts to maintain low lymphoma should be considered for people with EBV infection.
  F. Irshaid , K. Mansi and T. Aburjai
  The aim of this study was to evaluate the effects of essential oil extracted from aerial parts of Artemisia sieberi in normal and alloxan induced diabetic rats. Fifty rats were divided into five groups of 10 each. Group I normal rats received 1 mL day-1 of dimethyl sulfoxide (control); group II normal rats received a single dose (80 mg kg-1 b.wt.) of essential oil extract of Artemisia sieberi; group III diabetic rats received 1 mL day-1 of dimethyl sulfoxide; group IV diabetic rats received the oil extract (80 mg kg-1 b.wt.); group V diabetic rats received metformin (14.2 mg kg-1 b.wt.). All treatments were orally administered once a day for six weeks. Changes in blood glucose concentration, body weight and food and water intake were measured and the data obtained were compared with that of metformin. The essential oil extract significantly (p<0.05) lowered blood glucose level as well as food and water intake in diabetic rats accompanied by an increase in body weight gain with no apparent side effect when compared with untreated diabetic rats. These effects were found to be closely similar to that of metformin, a common antidiabetic drug. On other hand, no apparent improvement on body weight gain in diabetic rats treated with metformin. In addition, for all parameters measured, the oil extract showed no effect in normal rats. In conclusion, the essential oil of Artemisia sieberi exhibited antidiabetic activity in alloxan-induced diabetic rats. Present findings support the possible use of the essential oil of Artemisia sieberi as a remedy for diabetes mellitus in humans.
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