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Articles by F. He
Total Records ( 2 ) for F. He
  L Guo , W Ying , J Zhang , Y Yuan , X Qian , J Wang , X Yang and F. He
 

Mutations in the TSC1 and TSC2 genes lead to tuberous sclerosis complex (TSC), which is characterized clinically by mental retardation, epilepsy, and benign tumors affecting multiple tissues. Numerous components of the TSC protein complex remain uncharacterized. Here we report the purification of the TSC1 complex under physiological conditions using a proteomic strategy. We purified the TSC1 protein complex using a tandem affinity purification method and identified a protein complex containing 139 components. Two known binding proteins of TSC1 (TSC2 and DOCK7) were identified along with other new potential partners, which cover reported and novel TSC1 functional categories. Bioinformatics and biochemical methods were used to evaluate the observed protein–protein interactions. A comparative analysis with a published expression proteomics/genomics study of TSC1 revealed more than 20 common candidates that might be functionally relevant. The data set provides new directions in which to expand our knowledge of the functions of TSC1 and the mechanisms of TSC. The results are highly reliable, which is reflected by the identification of a few reported partners of TSC1 and many TSC1/2-regulated proteins. Interestingly, many new functional categories were identified, such as DNA repair, which provide novel hints to the function of TSC1. Moreover, a few neuronal disease-related proteins that might regulate the normal functions of neurons were identified. Thus, the results suggest that many of the new interactions should be biologically significance. It will be interesting to further investigate the regulatory mechanisms of these components.

  C. Zhao , Q. Luo , F. He , F. Peng , X. Xia , F. Huang and X. Yu
 

Aim

To determine the relationship between HbA1c and mean blood glucose concentrations by using HbA1c-mean blood glucose formulae for people on continuous ambulatory peritoneal dialysis.

Methods

A total of 305 people on continuous ambulatory peritoneal dialysis, including 13 people with Type 1 diabetes mellitus, 161 people with Type 2 diabetes mellitus and 131 people without diabetes, from a single peritoneal dialysis centre at the First Affiliated Hospital of Sun Yat-sen University, were enrolled between January 2006 and June 2011. Serum HbA1c concentration was measured quarterly and other laboratory variables, including blood glucose, were measured every month. The formulae were established using regression analysis and adjusted for other factors. The estimated blood glucose level calculated using our formulae was compared with that using previous formulae namely the Diabetes Control and Complications Trial and A1c-Derived Average Glucose formulae for people not on dialysis and the Hoshino formula for people on haemodialysis.

Results

The HbA1c-mean blood glucose formulae obtained by linear regression analysis were: 1) mBGmmol/l = 0.107 x HbA1c(mmol/mol) + 1.764 [adjusted R2 (inline image)  = 0.494]; 2) mBGmmol/l = 0.101 x HbA1c (mmol/mol) − 0.001 x Cr (μmol/l) + 2.850 (inline image = 0.507); 3) mBGmmol/l = 0.102 x HbA1c (mmol/mol) − 0.095 x Alb (g/l) + 5.394 (inline image = 0.521); and 4) mBGmmol/l  = 0.099 x HbA1c (mmol/mol) − 0.001 x Cr (μmol/l)−0.084 x Alb (g/l) + 5.754 (inline image = 0.526), where mBG is mean blood glucose, Cr is serum creatinine and Alb is serum albumin. These new formulae performed as well as or better than previous formulae.

Conclusions

The relationship between HbA1c and mean blood glucose for people on continuous ambulatory peritoneal dialysis differs from that for people not on dialysis or for those on haemodialysis. Clinicians and patients can determine glycaemic control targets by applying our formulae.

 
 
 
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