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Articles by F. Falaki
Total Records ( 3 ) for F. Falaki
  M. Amirchaghmaghi , F. Falaki , N. Mohtasham and M. Imanimoghaddam
  The aim of this study was to determined demographic, clinical and radiographic features of Central Giant Cell Granuloma (CGCG) of the jaws, for the first time, in north east Iran. In this retrospective study, records of patients with definitive diagnosis of CGCG were extracted from the archive of our faculty from 2004 to 2007. The patient ’s age, sex, duration and clinical features of the lesions, were evaluated. Radiographs were evaluated for radiographic patterns. Of 1232 existing files in our archive (between 2004 and 2008), 18 cases were diagnosed as CGCG. The age range of our patients was between 7 to 65 years with the mean age of 21.5 years. Most of cases (61.1%) were presented in females and 7 cases in males. Most lesions were located in the mandible (83.3%). The most common finding recorded in our patients was a Painless bony expansion of the jaw. Cortical perforation and soft tissue expansion was reported in 9 cases. In most cases, a well defined multilocular radiolucency was observed in OPG, while tooth displacement was seen only in 7 cases. Although, demographic and clinical findings of patients with CGCG in our area were similar to other studies, but some differences were observed in radiographic examination.
  Z. Delavarian , A. Pakfetrat , F. Falaki , M. Pazouki and N. Pazouki
  It seems that Oral Squamous Cell Carcinoma (OSCC) in young adults is different from OSCC in older patients especially in risk factors. No significant habits are seen in younger patients. It is claimed that viral infections, especially human papillomavirus, are associated with several human carcinomas, especially oral cancers. The aim of this study was to investigate the presence of viruses in Oral Squamous Cell Carcinoma (OSCC) in young patients (20-40 years old) attending Mashhad Dental Faculty from 1996 to 2009 for the first time in Iranian population. Twenty one formalin-fixed, paraffin-embedded sections of patients under 40 years with clinical diagnosis of OSCC, who had referred to Mashhad Dental Faculty from 1996 and 2009, were evaluated for DNA extraction. All specimens were tested for presence of Human papilloma virus, Epstein-Barr virus, Herpes simplex virus type 1 and Cytomegalovirus virus. From 21 specimens, viruses were detected only in three cases. Two samples were positive for EBV and the third one was co-infected with EBV and HSV-1. All of our specimens were negative for HPV and CMV. We concluded that viruses had no important role in OSCC in our young patients. Further researches are needed to clarify this role and to identify other possible risk factors.
  A. Pakfetrat , F. Falaki , M. Sankian and H. Abbaszadeh
  It was hypothesized that serum level of immunoglobulins may play a role in the pathogenesis of oral mucosal diseases but little is known about the role of salivary immunoglobulins in the pathogenesis of these diseases. The aim of this study was to investigate the possible alterations in salivary immunoglobulin A (IgA-s) level in patients with oral aphthous ulcers and its relation with clinical parameters. Level of IgA was measured by "ELISA" test in the resting whole saliva of 24 patients with acute Recurrent Aphthous Ulceration (RAU) and during remission and the results were compared with 24 healthy volunteers. IgA was increased in acute RAU in comparison with healthy controls. Results demonstrated a significant increase in salivary IgA level in active lesions in relation to quiescence phase. No differences were found in salivary IgA level between major and minor acute RAU and other clinical parameters. The results of our study suggest a possible role of mucosal immune system in the pathogenesis of these lesions. It is reasonable to postulate that modulation of salivary immune system in vivo or production of immune materials in vitro can be efficient in the prevention or control of aphthous lesions.
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