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Articles by F. D Fang
Total Records ( 1 ) for F. D Fang
  L. L Zhu , Y Liu , A. F Cui , D Shao , J. C Liang , X. J Liu , Y Chen , N Gupta , F. D Fang and Y. S. Chang

Peroxisome proliferator-activated receptor- coactivator-1 (PGC-1) is a key regulator of cellular energy metabolism and regulates processes such as adaptive thermogenesis, hepatic gluconeogenesis, fatty acid oxidation, and mitochondrial biogenesis by coactivating numerous nuclear receptors and transcription factors. Here, we demonstrate the presence of the ERR binding site in the regulatory sequence of the glucokinase gene and that PGC-1 coactivates ERR to stimulate the transcription of glucokinase. Simultaneous overexpression of PGC-1 and ERR potently induced the glucokinase gene expression and its enzymatic activity in primary hepatocytes; however, expression of either PGC-1 or ERR alone had no significant effect. Electrophoretic mobility shift and chromatin immunoprecipitation assays revealed the interaction of ERR with the glucokinase promoter. Finally, the knockdown of endogenous ERR with specific siRNA (siERR) or pharmacological inhibition of ERR with XCT790 attenuated insulin-induced glucokinase expression. Taken together, this research identifies glucokinase as a novel target of PGC-1/ERR and underscores the regulatory function of ERR in insulin-dependent enzyme regulation.

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