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Articles by F Zanca
Total Records ( 2 ) for F Zanca
  F Zanca , D. P Chakraborty , G Marchal and H. Bosmans

Although the receiver operating characteristic (ROC) method is the acknowledged gold-standard for imaging system assessment, it ignores localisation information and differentiation between multiple abnormalities per case. As the free-response ROC (FROC) method uses localisation information and more closely resembles the clinical reporting process, it is being increasingly used. A number of methods have been proposed to analyse the data that result from an FROC study: jackknife alternative FROC (JAFROC) and a variant termed JAFROC1, initial detection and candidate analysis (IDCA) and ROC analysis via the reduction of the multiple ratings on a case to a single rating. The focus of this paper was to compare JAFROC1, IDCA and the ROC analysis methods using a clinical FROC human data set. All methods agreed on the ordering of the modalities and all yielded statistically significant differences of the figures-of-merit, i.e. p < 0.05. Both IDCA and JAFROC1 yielded much smaller p-values than ROC. The results are consistent with a recent simulation-based validation study comparing these and other methods. In conclusion, IDCA or JAFROC1 analysis of FROC human data may be superior at detecting modality differences than ROC analysis.

  E Shaheen , F Zanca , F Sisini , G Zhang , J Jacobs and H. Bosmans

Digital breast tomosynthesis is a new three-dimensional (3D) breast-imaging modality that produces images of cross-sectional planes parallel to the detector plane from a limited number of X-ray projections over a limited angular range. Several technical and clinical parameters have not yet been completely optimised. Some of the open questions could be addressed experimentally; other parameter settings cannot be easily realised in practice and the associated optimisation process requires therefore a theoretical approach. Rather than simulating the complete 3D imaging chain, it is hypothesised that the simulation of small lesions into clinical (or test object) images can be of help in the optimisation process. In the present study, small 3D objects have been simulated into real projection images. Subsequently, these hybrid projection images are reconstructed using the routine clinical reconstruction tools. In this study, the validation of this simulation framework is reported through the comparison between simulated and real objects in reconstructed planes. The results confirm that there is no statistically significant difference between the simulated and the real objects. This suggests that other small mathematical or physiological objects could be simulated with the same approach.

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