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Articles by Eyong Ubana Eyong
Total Records ( 2 ) for Eyong Ubana Eyong
  Patrick Ekong Ebong , Item Justin Atangwho , Eyong Ubana Eyong and Godwin Eneji Egbung
  Polyherbal therapy is said to be a current pharmacological principle having the advantage of producing maximum therapeutic efficacy with minimum side effects. We assessed the antidiabetic efficacy and hence the impact on biochemical indices of toxicity by a combination of extracts from neem and bitterleaf. Thirty rats, 25 diabetic and 5 non-diabetic rats, were used for the study. The diabetic rats were divided equally into five groups and respectively treated: saline (diabetic control), extracts from neem and bitterleaf combined, neem only, bitterleaf only and chlorpropamide for a 24 day period. After oral administration of the first dose of extract (400 mg kg¯1 b.w.) and chlorpropamide (4.286 mg kg¯1 b.w.), blood glucose was monitored in vivo at various time intervals for 9 h, thereafter daily administration continued for 24 days. Whereas single dose treatment with neem only showed peak reduction (28.56%) an hour after, treatments with combined extracts, bitterleaf and chlorpropamide had their peak reductions all at the 7th hour (24.78, 47.31 and 60.51%, respectively). Percentage reductions in blood glucose relative to their initial values at the end of treatment were 71.05, 44.95, 88.63 and 75.83 for combined extract, neem, bitterleaf and chlorpropamide respectively. The decrease in blood glucose for the groups treated with combined extracts and bitterleaf only compared well (p<0.01) with chlorpropamide and non diabetic control, but not with neem alone. Determination of markers of hepatotoxicity in serum including GPT and GOT activities, total protein, albumin and urea indicated that, of the four treatments, neem provides the best protection against hepatic dysfunction. In the group treated with combined extracts these alternate selective advantages of neem and bitterleaf were expressed as a positive synergy, hence more beneficial than individual treatments.
  Saviour Udo Ufot , Uduak Onofiok Luke , Friday Effiong Uboh and Eyong Ubana Eyong
  Background and Objective: Crude oil has been reported to cause various toxic effects in the body. And vitamins C and E are among the antioxidants known to play important role in attenuating chemical toxicants-induced toxicities in the biological systems. This study aimed at assessing the protective effect of vitamin C against crude oil induced atherosclerosis in rats. Materials and Methods: Twenty four male albino Wistar rats, weighing 150-180 g, used in this study were distributed into four groups (1, 2, 3 and 4), with 6 rats each. Group 3 animals were orally administered 60 mg of NBLCO kg–1 b.wt., while group 4 animals were orally administered 60 mg NBLCO kg–1 b.wt. and co-administered 200.0 mg of vitamin C kg–1 b.wt., of the rats daily for 30 days. The animals in groups 1 and 2 served as the controls receiving only distilled water and vitamin C, respectively. At end of the experimental period, the animals were sacrificed and blood samples collected through cardiac puncture for plasma lipid profile analyses. Total plasma cholesterol (TC), triacylglycerol (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL) levels and atherogenic indices were determined in rats orally exposed to Nigerian Bonny light crude oil (NBLCO) and co-administered vitamin C. Results: The results of the study showed that exposure to crude oil is a risk factor for atherosclerosis by producing a significant (p<0.05) increase in plasma TC, TG, LDL and VLDL levels and the evaluated atherogenic indices (Group 3), compared to the control (Group 1). The plasma TC, TG, LDL, VLDL levels and the atherogenic indices recorded for rats exposed to NBLCO and co-administered vitamin C (Group 4) were significantly (p<0.05) lower, compared to the rats exposed to NBLCO only (Group 3). Conclusion: This study demonstrated that vitamin C is capable of providing protection against crude oil induced atherosclerotic conditions by regulating serum lipids profiles and atherogenic indices in rats. It may be concluded that vitamin C is potent in preventing cardiovascular disorders associated with crude oil induced atherosclerotic conditions.
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