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Articles by Evren KOC
Total Records ( 3 ) for Evren KOC
  Basaran Karademir , Guler Karademir , Serdal Tarhane , Unal Ciftci , Evren Koc , Yusuf Ersan and Kadir Bozukluhan
  This study was carried out to determine the changes of Cu, Zn, Fe, Ca, Mg, K and Na levels in liver during treatment of oral ampicillin in mice. The investigation was supported by serum ALT and AST enzyme activities, serum Total Protein (TP), Albumin (ALB), Globulin (GLB) levels determinations. Twenty one male Swiss albino mice (weighing 28.36±2.33 g, aged 4 months) were used for this study. The standard commercial diet was given to all groups. First group (A) were used control and took only tap water. Other groups were received water with ampicillin. Dose of ampicillin for second (B) and third (C) groups were as follows; 8 and 40 mg/100 mL in drinking water. Dry ashing method and Flame Atomic Absorption Spectrometer (FAAS) were used for determination of minerals. Statistically significant increase (minimum p<0.05) for Cu, Ca and Na and decrease for K were observed. Significant positive correlation between Cu-Ca, Cu-Na, Zn-Mg, Ca-Na, Mg-K (minimum r = 0.450, p<0.05) and negative correlation between Cu-K (r = 0.456, p<0.05) were observed. There was a significant difference in AST levels of groups (p<0.001) but not other serum parameters of ALT, TP, ALB and GLB. These results indicate that oral ampicillin treatment affect liver Cu, Ca, Na and K levels. Therefore, this fluctuation must be considered on ampicillin applications during antimicrobial therapy.
  Yusuf ERSAN , Evren KOC , Ismail ARI and Basaran KARADEMIR
  Fluoride intake in high doses has toxic effects on various organs. Chronic fluorosis results in tubular degenerations, inflammation, fibrosis, parenchymatous nephritis, cloudy swellings, and dilations of convoluted tubules. In addition to these effects, fluoride causes deteriorative effects on the skeleton, teeth, and soft tissues. The goal of this study was to examine the impacts of chronic fluorosis on the liver tissues of mice. Materials and methods: One control group and 3 experimental groups, each group consisting of 4 male and 4 female mice, were formed to conduct the experiment. A stock solution including 2000 ppm fluoride was prepared by solving 4.44 g of NaF in 1 L of distilled water. Water with 10, 20, and 40 ppm fluoride was obtained by diluting the stock solution to give to the animals. Animals in the control group had free access to tap water with 0.3 ppm fluoride. Animals in experimental group 1 were orally given distilled water with 10 ppm fluoride, water with 20 ppm fluoride was orally given to the animals in experimental group 2, and the animals in experimental group 3 were orally given distilled water containing 40 ppm fluoride for 90 days. The animals were killed under light ether anesthesia to obtain specimens from the livers. Slides were prepared under the light microscope to examine histopathological anomalies and then photographs were taken. Results: Histopathological disorders were observed on the slides prepared from the liver specimens of the animals exposed to chronic fluorosis depending on doses of chemicals given to the animals. Hyperemia, local necrosis, hydropic degeneration, vacuolar degenerations, and swelling on hepatocytes around the central vein were detected. Conclusion: Depending on the doses of fluoride applied to the animals, degenerations in the tissues around the central vein increase.
  Yusuf ERSAN , Ysmail ARI and Evren KOC
  In this study, 4 experimental groups and 1 control group containing adult mice (Mus musculus var. albinos) were used to examine the effects of 2 different cadmium compounds, namely cadmium para hydroxybenzoate, which was newly synthesized, and cadmium chloride on the liver of mice. In various test concentrations, both cadmium compounds were intraperitoneally injected into adult miceĀ  every day for 15 days. With standard histological techniques samples were obtained from the livers of the mice. Slides were prepared and examined with light microscopy (Nikon Eclipse E600) and histopathological structures were observed.
 
 
 
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