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Articles by Eryati Darwin
Total Records ( 2 ) for Eryati Darwin
  Nurhayati , Nuzulia Irawati , Eryati Darwin and Nur Indrawaty Lipoeto
  Background and Objective: Geohelminth is a common cause of chronic infections in humans. Worm infections have been shown to have a protective effect against some diseases. The effect is related to the ability of the worm to modulate the host immune response through Th2. The aim of study was to investigate the correlation between IL-10 levels and blood cholesterol and glucose in geohelminth positive human subjects with mature immune systems. Materials and Methods: Stool examination for geohelminth was done by direct method using iodine and by Kato Katz method. IL-10 levels were measured by indirect enzyme-linked immunosorbent assays (ELISA) method. Total plasma cholesterol levels were examined by CHOD-PAP method and fasting blood glucose was measured using hexokinase method. Results: All subjects infected with geohelminth classified as a mild infection. There was no correlation between IL-10 levels and EC/GC (p>0.05) but there was a negative correlation between IL-10 levels with TC levels (p<0.01) and between IL-10 levels and FBG levels (p<0.01). Conclusion: A negative correlation between IL-10, TC and FBG further strengthens support for the role of Th2 especially IL-10 to low cholesterol and blood glucose levels in geohelminth infections.
  Gusti Revilla , Eryati Darwin , Yanwirasti and Fedik A. Rantam
  Background and Objective: Burn is a public health problem, it causes physical disability even death. Treatment of burn wound has been conducted in various ways, but the satisfactory healing has not been provided. Bone marrow-derived mesenchymal stem cells (BM-MSCs) treatment is one of attempt to burn recovery, accelerate wound healing and angiogenesis. This study aimed to investigate the effect of allogeneic BM-MSC treatment on the expression of collagen type I and integrin α2β1 in burn skin tissue of rat observed on day 14. Materials and Methods: Twelve Wistar rats divided into two groups, control group (injected with phospate buffer solution) and treatment group (injected with BM-MSC). Rat was anaesthetized with xylazine and ketamine (ratio 1:1), fur of rat’s back was shaved and full thickness burn was made by boiling plate in hot water for 30 min and patched on the back for 20 min. The burns were covered by tegaderm film and elastomult haft. Antalgin as an analgetic was injected to rats during observation process. Burns of rat was observed on day 14. In this study one-way analysis of variance test and Tukey as a further test were analyzed. Results: The results showed that the healing time of allogeneic BM-MSC treatment on burn skin tissue rats was faster, the thickness of collagen type I in burn skin tissue of rats was thicker (0.977 μm) than controls (0.475 μm) and statistically demonstrated significant differences (p = 0.000). The average percentage of integrin α2β1 expression was higher (2.94%) than control group (2.34%), but the differences were not statistically significant (p = 0.176). Conclusion: The study concluded that BM-MSC treatment was able to accelerate the healing process of burns by increasing the thickness of the collagen and the percentage of integrin α2β1, thus accelerated the cell migration involved during wound healing.
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