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Articles by Erdem Yesilada
Total Records ( 2 ) for Erdem Yesilada
  Gulcan Avci , Ismail Kucukkurt , Esra Kupeli Akkol and Erdem Yesilada
  Escins, a triterpene glycoside mixture obtained from the ethanol extract of Aesculus hippocastanum L. (Hippocastanaceae) seed, was evaluated for its in vivo effects on the plasma levels of some hormones (leptin, insulin, FT3, FT4) and biochemical parameters (glucose, triglyceride, total cholesterol, HDL - C, LDL - C concentrations) in mice fed with a high fat diet for 5 weeks. A high fat diet induced a remarkable increment in the plasma leptin (p <0.01), total cholesterol (p <0.01) and LDL - C (p <0.001) concentrations compared to control group animals. Combined administration of a high -fat diet with escins decreased leptin (31.6%) (p<0.05) and FT4 (36.0%) (p<0.05) levels, increased HDL - C concentration (17.0%), while remained ineffective on LDL - C concentration in mice. Results have shown that escins may have beneficial effects in the understanding of obesity.
  Esra Kupeli Akkol , Didem Deliorman Orhan , Ilhan Gurbuz and Erdem Yesilada
  Honey - bee pollen mix (HBM) formulation is claimed to be effective for the treatment of asthma, bronchitis, cancers, peptic ulcers, colitis, various types of infections including hepatitis B, and rheumatism by the herb dealers in northeast Turkey. In the present study, in vivo antinociceptive, anti - inflammatory, gastroprotective and antioxidant effects of pure honey and HBM formulation were evaluated comparatively. HBM did not show any significant gastroprotective activity in a single administration at 250 mg/kg dose, whereas a weak activity was observed after three days of successive administration at 500 mg/kg dose. On the other hand, HBM displayed significant antinociceptive (p <0.01) and anti - inflammatory (p <0.01) activities at 500 mg/kg dose orally without inducing any apparent acute toxicity or gastric damage. HBM was also shown to possess potent antilipidperoxidant activity (p <0.01) at 500 mg/kg dose against acetaminophen - induced liver necrosis model in mice. On the other hand, pure honey did not exert any remarkable antinociceptive, anti - inflammatory and gastroprotective activity, but a potent antilipidperoxidant activity (p <0.01) was determined. Results have clearly proved that mixing pure honey with bee pollen significantly increased the healing potential of honey and provided additional support for its traditional use. Total phenolic and flavonoid contents of HBM were found to be 145 and 59.3 mg/100 g of honey, which were estimated as gallic acid and quercetin equivalents, respectively.
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