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Articles by Enver BEYTUT
Total Records ( 3 ) for Enver BEYTUT
  Enver BEYTUT , Mitat SAHİN , Serpil ERGİNSOY and Mahmut SÍZMEN
  The present study examined the mammary glands and supramammary lymph nodes of cows with a history of abortion due to Brucella abortus, and presents the histopathological, immunohistochemical, and bacteriological results. The study included 11 Brucella-seropositive cows that aborted during their first gestation. Histopathologically, the mammary glands showed lymphoplasmacytic and histiocytic interstitial mastitis. The lymph nodes had lymphofollicular hyperplasia and medullary plasmacytosis. Immunohistochemistry results showed brucellar antigens, predominantly in the cytoplasm of macrophages, and neutrophils in the intralobular interstitium and periductal stroma in the udders of 3 cows. Desquamated alveolar epithelium also indicated intense immunopositivity. In the lymph nodes, macrophages containing the antigen were frequently observed in the medullary region. B. abortus biotype 3 was isolated from the udders and supramammary lymph nodes of 4 cows. Although the most specific procedure for diagnosing the disease is isolation of the causative organism, for suspected cases in which the bacteriologic culture is negative or the material is fixed in formalin, immunohistochemistry may be used as a diagnostic tool for the detection of Brucella organisms.
  Enver BEYTUT , Atilla AKCA and Halil İbrahim GOKCE
  The present study was aimed at pathologically and immunohistochemically evaluating the effects of interferon gamma (IFN-γ) and aminoguanidine (AG) in rats experimentally infected with Fasciola hepatica. A total of 44 Wistar rats were divided into 4 groups. With the exception of the controls (fourth group), the remaining rats were infected orally with 25 metacerceria of F. hepatica. The first group was administered 0.2% AG in drinking water daily, in order to block nitric oxide (NO) production. The second group was administered 250 units of IFN-γ daily, in order to stimulate NO synthesis. The third group was administered a placebo only. At the end of the 2 month experimentation period all the rats were killed under ether anesthesia and necropsied. Migrating tracts, necrosis, and enlargement of the main bile duct were the predominant lesions in infected livers. The parasite burden was lower in the IFN-γ-treated rats than rats in the other groups. Acute migrating tracts were occluded with numerous erythrocytes, necrotic hepatocytes, and neutrophils and surrounded by mononuclear cell infiltration interspersed with eosinophils. Chronic migrating tracts were generally repaired with fibrous connective tissue and surrounded by chronic inflammatory infiltrate. Immunohistochemistry detected CD3+ T and CD79αcy + B lymphocyte infiltration, λ IgG + plasmocytes and PCNA-positive cells in the infected livers, hepatic and mesenterial lymph nodes, and Peyer′s patches. Given the low numbers of parasites and the limited repair in the liver of the animals administered IFN-γ and the severity of the lesions in the livers of the animals administered AG, it was concluded that IFN-γ positively affected the immune system and that AG blocked NO production in the animals.
  Enver BEYTUT and Burhan OZBA
  In this report, congenital lymphoma of B-cell lineage in a Brown Swiss calf is described. A large mass was seen on the head of the calf at birth. At necropsy, multiple masses were found on the skin and internal organs. A histopathological examination showed atypical lymphoid cells separated by connective tissue. None of the tumor cells showed a positive reaction to CD3, but the cells were immunopositive for CD79acy. A CD45+ reaction confirmed a hematopoietic origin of the neoplasm. Tumor cells were also positive for lambda light chain IgG (λ IgG). Proliferating cell nuclear antigen (PCNA) immunostaining showed diffuse nuclear positivity. Terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) staining found numerous apoptotic bodies. The neoplasm was diagnosed as a congenital lymphoma of B-cell lineage.
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