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Articles by Enqi Liu
Total Records ( 3 ) for Enqi Liu
  Wentao Sun , ChunLing Lei , Sihai Zhao , LiLun Wang , ChunChao Bi , Rui Wang , XiaoLiang Zhou , Enqi Liu and MingXia Chen
  Observation on morphological and ultrastructural changes of retinopathy in diabetic rabbit long been fed with high sucrose and fat fodders. Use alloxan to establish diabetic rabbit model. Feed the rabbits with high sucrose and fat fodders conduct a Fluorescein Fundus Angiography test (FFA) every 3~4 months to observe morphological changes in retina. Conduct Transmission Electron Microscopy (TEM) examination on eyeball of the model 10~12 months later so as to get wise to the ultrastructural changes in the rabbit retina. The FFA indicated that with the protraction of the disease, Fluorescein Isothiocyanate (FITC) leakage and neo-vasulariztion shadows similar to that of human were seen in the diabetic rabbit model. TEM examination showed that no abnormality was seen in the ultrastructure of the rabbit retina of normal group. The retina of the diabetic rabbit exhibited microfilament and focal dissolving, myelin sheath structure loosening and partial demyelination changes, pericyte mitochondrion tumefaction, endothelial cell layering, space increasing, mitochondrion tumefaction on the nerve fiber layer. Glycogenosome accumulation was seen in the outer nuclear layer retina cells.
  Guangwei Zhang , Kena Wei , Enqi Liu , Yanli Wang , Yafeng Li , Qi Yu , Yulong Chen , Bingqiao Huang , Shemin Lu , Xicai Yan and Sihai Zhao
  What the effects of rosiglitazone treatment on the fatty liver remained controversial. The aim of this study was to investigate the effects of rosiglitazone on fatty liver of rabbits. Thirty nine male Japanese white rabbits were divided into three groups, the rosiglitazone treatment Group 1 (3 mg/kg/day), rosiglitazone treatment Group 2 (6 mg/kg/day) and the control group and were fed a High Fat and Cholesterol Diet (HFCD) for 8 weeks. The Rabbit Fatty Liver Model was successfully established. HFCD resulted in a notable increase in plasma Total Cholesterol (TC) and plasma Triglycerides (TG). However, there was no significant difference among three groups in the plasma and liver parameters of TG and TC. The total body fat weight and the ratio of fat weight to body weight were higher in the rosiglitazone treatment groups vs. the control group while the ratio of the main organs and body weight were lower in the rosiglitazone treatment groups as compared to the control group. Hematoxylin and Eosin (HE) staining of liver suggested that rosiglitazone treatment led to a slight improvement of fatty liver in HFCD rabbits but the difference was not significant. The findings demonstrate that rosiglitazone treatment did not lead to significant improvement of fatty liver in rabbits.
  Guangwei Zhang , Yulong Chen , Yan Lin and Enqi Liu
  Cardiovascular disease is currently the major cause of mortality and morbidity in developing and developed countries. Atherosclerosis is the core of cardiovascular disease and is complex inflammatory process. Many animal species have been used to investigate the pathogenesis of atherosclerosis. However, the most useful animal models have been restricted to genetically modified mice or larger animal models including rabbits, pig and non-human primates. Mouse models are widely used for atherosclerosis research due to genetic manipulation. Murine atherosclerosis are different from that of human. Thus, the models are used for investigation of biological processes of atherosclerosis. Rabbits do not develop spontaneous atherosclerosis but they are highly responsive to cholesterol diet and develop plaque in a short time. Pig and monkey are better suitable models because their plasma levels and atherosclerotic plaque are similar to that of human. However, these models are not widely used. Relatively high cost and ethical concern may be major causes.
 
 
 
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