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Articles by Emmanuel O. Ajani
Total Records ( 2 ) for Emmanuel O. Ajani
  Emmanuel O. Ajani , Bamidele A. Salau , Fisayo A. Bamisaye and Wasiu E. Olooto
  Reports on the role of calcium on predisposition to cardiovascular disease have been rather inconsistent while studies on its interaction with other medications are ongoing. Researchers therefore, investigated the effect of separate and combine administration of calcium supplement with artemisinin-based combination drug on hepatic and serum lipid profile. A total of 32 male wistar rats were randomly assigned into 4 groups of 8 rats each. The control (Group A) received water. Group B and D were placed on 10 mg kg-1 calcium twice daily for 4 weeks. On the 30th day, therapeutic dose of artemisinin-based combination was simultaneously administered to group C and D twice daily for 3 days. All the rats were then sacrificed after 12 h fasting, blood was withdrawn and the liver removed and homogenized in an appropriate buffer. Biochemical analysis showed no significant (p>0.05) variation in hepatic triaacylglycerol in all the treated groups whereas calcium supplementation was observed to induce a significant (p<0.05) reduction in hepatic cholesterol. Significant elevations due to calcium supplementation were also observed in serum total cholesterol, LDL cholesterol level and atherogenic risk index with a concomitant reduction in serum HDL cholesterol. No significant change was observed in serum total cholesterol, triacylglycerol and serum lipoproteins in all other treatment groups. This study suggests that calcium supplementation may predispose to cardiovascular disease and that its co administration with ACT may not aggravate nor reduced the predisposition risk.
  Emmanuel O. Ajani , Mutiu A. Alabi , Sunday Awe , Latifat B. Ibrahim , Olajumoke A. Awoyemi and Sekinat A. Balogun
  Background and Objective: Sweet potato (Ipomoea batatas) is the 6th most important food crop and possesses anticancer, antidiabetic and anti-inflammatory properties. This study investigated the effect of sweet potato wine in altered biochemical indices in cholesterol fed rats. Materials and Methods: Wister albino rats weighing between 90-120 g were randomized into 8 groups of 10 rats each fed with fresh sweet potato and sweet potato extract. Group 1 (control) were fed normal rat feed and were given sterile placebo (distilled water). Group 2 (negative control) were fed normal rat feed and 2.5% cholesterol. Group 3 (positive control) were fed normal diet, 2.5% cholesterol and standard red wine (400 mL/70 g). Group 4-7 were the treatment groups as follows: TI (2.5% cholesterol+400 mL/70 g potato wine), T2 (2.5% cholesterol+800 mL/70 g potato wine), T3 (400 mL/70 g potato wine) and T4 (800 mL/70 g potato wine). Group 8 (standard control) were fed normal diet and standard red wine (400 mg/70 g). The wines and the cholesterol were daily administered at 9 am and 4 pm, respectively for 5 weeks and the animal were sacrificed 24 h after the last administration. Results: The sweet potato wine and extract: restores abnormalities in lipid profiles in the cholesterol fed rats, does not have a significant effect on the serum renal function biomarkers and the liver function biomarkers were significantly increased. Conclusion: The study suggests that administration of sweet potato wine would be beneficial in restoring lipid profiles while eliciting liver damage which might not have a significant effect on kidney function.
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