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Articles by Eman Salah Abdel-Reheim
Total Records ( 2 ) for Eman Salah Abdel-Reheim
  Adel Abdel Moneim , Eman Salah Abdel-Reheim , Hamdi Helmy and Wessam Addaleel
  Background and Objective: The management of diabetic hyperglycemia, dyslipidemia and oxidative stress status are the key elements in the protection of diabetic complications. The present study was hypothesized to evaluate the antidiabetic, antihyperlipidemic and antioxidant effects of thymoquinone on streptozotocin-induced diabetic albino rats. Materials and Methods: The rats were divided into 2 categories; pre-treated and treated groups. Thymoquinone (50 mg kg–1 b.wt.) was intraperitoneally injected day after day for 2 weeks pre and 2 weeks after induction of diabetes for the pre-treated group and 2 weeks after induction of diabetes for treated group. Results: The current study revealed that thymoquinone administration caused amelioration in hyperglycemia, hypoinsulinemia, dyslipidemia, impaired antioxidant defense system and upregulation to PPAR-γ and GLUT4 genes expression as compared to the diabetic rats. Conclusion: The current results revealed the hypoglycemic, hypolipidemic and protective effects of thymoquinone against diabetes via potentiating insulin secretion and action, modulate PPAR-γ and GLUT4 genes expression and also by its potent antioxidant effect.
  Adel Abdel-Moneim , Ahmed Hosni , Eman Salah Abdel-Reheim and Ahmed Ismail
  Background and Objective: Ellagic acid (EA) is a natural polyphenol compound with promising anti-diabetic effects. This study examined the safe effects of EA from Padina boryana against fatty-sucrosed diet (FSD)/streptozotocin (STZ)-induced gestational diabetes mellitus (GDM), referring to the role of peroxisome proliferator-activated receptor gamma (PPARγ)/anti-inflammatory axis. Materials and Methods: Female albino Wistar rats were allocated into three groups. Group I fed with normal diet (ND). Group II and III were fed FSD for 8 weeks (five pre-gestational and three gestational). Rats of group III were administered with a daily oral dose of 50 mg kg–1 EA 1 week before mating onward. At the 7th day of the gestation, to induce GDM, FSD-fed dams were injected intraperitoneally with STZ (25 mg kg–1 b.wt.). Results: Pre-mating administration of EA controlled the body weight loss, hyperphagia, glucose intolerance and insulin resistance during the gestational period than in diabetic dams. EA also reduced levels of total cholesterols, triglycerides, hepatic lipid peroxidation, fructosamine and nitric oxide levels, while it significantly increased levels of high-density lipoprotein-cholesterol, liver glycogen, glutathione and catalase activity. In addition, EA supplementation markedly attenuated serum levels of tumor necrosis factor-alpha and leptin while adiponectin level was elevated. These effects coincided with up-regulation of the visceral adipose tissue PPARγ expression at term pregnancy. Besides, EA nearly normalized number of viable fetuses, implantation loss sites as well as fetal insulin and glucose levels. Conclusion: EA safely ameliorates gestational hyperglycemia in rats via potential association of PPARγ and anti-inflammatory biomarkers that suppress the oxidative stress status.
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