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Articles by Emad Elmasry
Total Records ( 2 ) for Emad Elmasry
  Mohammed Amin Mohammed , Rokia Anwar , Amany H. Mansour , Emad Elmasry and Gamal Othman
  Obesity is a chronic multi-factorial disease associated with serious increases in adiposity, morbidity and mortality rates. Ghrelin, leptin and adiponectin complexly interact to modulate appetite and mediate metabolic processes. The objective was to evaluate the effects of Bioenteric Intragastric Balloon (BIB) versus conservative therapy (diet and physical exercise) on plasma ghrelin, leptin, insulin and adiponectin in obese subjects. A total of 128 adult consecutive morbidly obese individuals were randomized into: BIB group comprised 84 patients treated with Intragastric Balloon and control group comprised 44 obese patients treated with conservative treatment only. In BIB group, insertion of balloon caused a significant reduction in body mass over a 6-months period compared with the control group. After one month, the levels of ghrelin increased significantly then gradually decreased, reaching the starting level three months after the removal of the balloon. Also, leptin level decreased significantly. In the control group, the corresponding of ghrelin and leptin levels remained relatively stable. In BIB group, adiponectin significantly increased as opposed to a transient increase in the control group. Conclusion: intragastric balloons in association with low-calorie diet are effective, safe, reversible, but short-lasting therapeutic endoscopic intervention in obese patients. The treatment with BIB causes significant changes in the levels of appetite-regulatory hormones beside a body mass reduction, changes in carbohydrate and lipid metabolism and improved co-morbidities.
  Mohammed Amin Mohammed , Nesreen Moustafa Omar , Abdelhadi M. Shebl , Amany H. Mansour , Emad Elmasry and Gamal Othman
  The correlation between celiac disease (CD) and type 1 diabetes (T1D) mellitus has been known for decades. However, the data assessing celiac disease prevalence in type 1 diabetic patients among Arab population especially in Egypt were scarce. This study assessed celiac disease prevalence and its genotypic profile in Egyptian type 1 diabetic patients and their non diabetic relatives and determined effects of gluten-free diet on diabetes control and anthropometry. A total of 500 outpatients {15-49 years; with type 1 DM (300; F/M: 168/132) and their non diabetic relatives (200; F/M: 91/109)} and another 300 age and sex matched healthy control were randomly enrolled and screened for CD by tissue transglutaminase (TTG) antibodies, HLA genotyping and distal duodenal biopsy. The demographic, clinical, anthropometric data and effects of gluten free diet were assessed. CD prevalence was 10.3, 2 and 0.3% in T1D, relative and control groups, respectively. The majority of CD patients (77.42%) carried the HLA-DQ2 in linkage with HLA-DRB1*03 alone (41.9%) or with other alleles (DRB1*01,*04,*07,*08,*09,*13). Eleven patients (35.48%) carried HLA-DQ8 either alone in three patients or with other alleles (DRB1*03,*07 in five and three patients respectively. Only one patient with positive TTG-IgG and normal histopathology had negative DQ2 and DQ8 but positive DRB1*7 and *11 haplotypes. CD is a frequent but commonly under-diagnosed among Egyptian T1D patients. HLA-DQ2 and DQ8 genotypes (in linkage with HLA-DRB1*3 and HLA-DRB1*4 alleles) responsible for CD development are highly prevalent in Egyptian CD patients with T1D.
 
 
 
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