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by
Elin Yulinah Sukandar |
Total Records (
5 ) for
Elin Yulinah Sukandar |
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Gunawan Pamudji Widodo
,
Elin Yulinah Sukandar
,
Sukrasno
and
I. Ketut Adnyana
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The aim of study was to isolate, characterize and elucidate
of the antifungal compounds from acetone fraction of Ageratum leaves
and to determine the antifungal activity of the isolated compounds. A
coumarin compound has been isolated from acetone fraction of Ageratum
leaves (Ageratum conyzoides L.) and chemical structure has been
elucidated based on UV, IR, NMR and mass spectra. This compound showed
an antifungal activity against the plant pathogenic fungi, Aspergillus
niger. A. niger is a fungus and one of the most common species
of the genus Aspergillus. It causes black mold on certain fruits
and vegetables such as grape, onion and peanuts and is a common contaminant
of food. The coumarin was tested for its antifungal activity against A.
niger by disk diffusion method. The MIC values of coumarin was 62.5
μg mL-1. |
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Elin Yulinah Sukandar
,
Joseph Iskendiarso Sigit
and
Levina Ferdiana Adiwibowo
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Earlier studies from our laboratory have indicated renal function improving action of corn silk and binahong in gentamicin-piroxicam induced kidney failure. This study was aimed to determine the effects of combination of cornsilk and binahong extracts on kidney failure model in rat and the effects of the extract combination on oxidative stress. Rats were divided into the positive control group, the group treated with 75 mg kg-1 of corn silk, the group treated with 100 mg kg-1 b.wt. of binahong, two groups treated with graded doses of combination of corn silk and binahong and the negative control group. Serum creatinine, urea, organ-to-body weight ratio of the kidney (kidney index) and renal histology were assessed to determine renal function. Meanwhile, the activities of lipid peroxidation, catalase and Superoxide Dismutase (SOD) were measured to analyse oxidative stress level. Administration of combination of the extracts at half dose resulted in marked depletion of serum creatinine and urea which was comparable to the results in corn silk-and binahong-treated groups. In addition, the extract combination was shown to reduce kidney index compared to that of the positive control group. The combination was further revealed to reduce renal damage histologically. Administration of the extract combination was demonstrated to attenuate kidney oxidative stress as shown by the reduction in lipid peroxidation and the increased activity of antioxidant enzymes, such as catalase and SOD. Taken together, results of this study suggest that corn silk in combination with binahong possesses renal function improving activity which is slightly better compared to the activity of each extract alone. The results further indicate that reduction of oxidative stress by each extract as well as their combination might be beneficial to the repair of renal damage. |
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Leni Herliani Afrianti Priyatno
,
Elin Yulinah Sukandar
,
Slamet Ibrahim
and
I. Ketut Adnyana
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The compound of 3β-hydroxy-sitosterol (1) and 2-metylester-1-H-pyrrole-4-carboxilyc acid were isolated from ethyl acetate extract of snake fruit (Salacca edulis Reinw) cv. Bongkok, (2). Inhibition of xanthine oxidase by the two compounds were evaluated against enzyme of xanthine oxidase. Compound 1 could be regarded as inactive, while compound 2 was found to be active with IC50 value of 48.86 μg mL-1. |
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Elin Yulinah Sukandar
,
Primal Sudjana
,
Joseph I. Sigit
,
Ni Putu E. Leliqia
and
Fetri Lestari
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Dyslipidemia is the major cause of atherosclerosis. A number of drugs that inhibit cholesterol synthesis has indicated to control lipid profile. However, these lipid lowering drugs are not free of side effect. Therefore a substance that less toxic and yet effective would be beneficial. Here we compared the anticholesterol effect of combination of garlic and turmeric extract, a herbal product, with a standard lipid lowering drug, simvastatin. Thirty nine people were recruited and randomized into two groups, Garlic-Turmeric (G-T) group (n = 19) received three times two capsules of garlic-turmeric extract (2.4 g day-1) and simvastatin group (n = 20) received placebo and 5 mg simvastatin to blind the subjects from knowing what drugs they get, for 14 weeks. Garlic-turmeric extract could improve lipid profile comparable with simvastatin (p = 0.366). There were no adverse event related to garlic-turmeric administration, even there was improvement in liver function at the end of the study. In conclusion garlic-turmeric extract could improve lipid profile comparable to simvastatin with no significant adverse event. |
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Elin Yulinah Sukandar
,
Nethiyakalyani Sunderam
and
Irda Fidrianny
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Temu kunci (Kaempferia pandurata (Roxb.)) has a number
of benefits and one of these is antibacterial. The rhizome is said to have antibacterial
activity against Streptococcus mutans, Lactocillus sp. and Candida
albicans. The aim of the study is to test the antibacterial activity of
Kaempferia pandurata (Roxb.) rhizome ethanol extract on methicillin-resistant
Staphylococcus aureus (MRSA), methicillin-resistant coagulase negative
Staphylococci (MRCNS), methicillin-sensitive Staphylococcus aureus (MSSA),
Bacillus subtilis and Salmonella typhi. Antimicrobial activity of the
extract was assayed by the microdilution method using Mueller Hinton Broth with
sterilized 96 round-bottomed microwells to determine the Minimum Inhibitory
Concentration (MIC) as well as to determine the time-kill activity. The MIC
of the extract was 16 ppm for both Bacillus subtilis and MRSA; 8 ppm
for both MSSA and Salmonella typhi and 4 ppm for MRCNS. Ethanol extract
of Kaempferia pandurata (Roxb.) showed antibacterial activity against
all the tested bacteria and was the most potent against MRCNS, with MIC
4 ppm. The killing profile test of the extract displayed bactericidal activity
at 8-16 ppm against MRSA, MSSA, Bacillus subtilis and Salmonella typhi
and bacteriostatic activity at 4 ppm towards MRCNS. |
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