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Articles by Efere Martins Obuotor
Total Records ( 2 ) for Efere Martins Obuotor
  Rita Maneju Sunday , Efere Martins Obuotor and Anil Kumar
  Background and Objectives: In India and many other Asian countries, traditional medicinal plants are used for treatment of various diseases. Under the category, Mimosa pudica is used as a traditional medicine for the treatment of numerous diseases including diabetes. In recent time, diabetes has become much common disease perhaps due to changed life style. Therefore, in the present study, antidiabetic effect of Mimosa pudica seeds ethanolic extract and extract fractions (n-butanol, ethyl acetate and n-hexane) was investigated in vivo in Wistar rats. Antioxidant study was carried out using in vitro and in vivo models. Materials and Methods: The free radical (2,2-Diphenyl-1-picrylhydrazyl and nitric oxide) scavenging activity and total antioxidant (flavonoid and phenol) contents of the extracts were determined in vitro by spectrophotometric method. In the in vivo studies, 100, 200 and 400 mg kg1 Mimosa pudica seeds ethanolic extract and 200 mg kg1 of each extract fractions were administered to streptozotocin (60 mg kg1) induced diabetic Wistar rats. Results: Mimosa pudica seed extracts possess moderate amount of antioxidants and scavenged 2,2-Diphenyl-1-picrylhydrazyl and nitric oxide free radicals. Mimosa pudica seed extracts also decreased fasting blood glucose level and lipid peroxidation (thiobarbituric acid reactive substances) and increased serum insulin, serum α-amylase and hepatic antioxidants (catalase and reduced glutathione) levels in 21 days treated diabetic rats. The ethyl acetate extract fraction scavenged 2,2-Diphenyl-1-picrylhydrazyl (65.41%) and nitric oxide (90.16%) radicals than the other extracts. The ethyl acetate extract fraction also exerted more antidiabetic activity and increased hepatic antioxidant levels than the other extracts and the untreated group. Conclusion: Mimosa pudica seeds exerted its antidiabetic effect by enhancing secretion of pancreatic insulin and α-amylase. Mimosa pudica seeds also possess antioxidant activity and therefore, can be employed in preventing hepatic damage associated with diabetes.
  Rita Maneju Sunday , Efere Martins Obuotor and Anil Kumar
  Background and Objective: The Asparagus adscendens root is used in ayurvedic medicine for the treatment of various diseases. In this study, the antioxidant properties of Asparagus adscendens root ethanolic extract and extract fractions (n-butanol, ethyl acetate and n-hexane) were investigated using in vitro models. Materials and Methods: The antioxidant activities were determined by 2, 2-Diphenyl-1-picrylhydrazyl, hydrogen peroxide and nitric oxide radical scavenging assays. The total antioxidant capacity, total flavonoid and total phenol content of the extracts were evaluated by spectrophotometric method. Results: The ethanolic extract and extract fractions exerted potent radical scavenging activities. Ethyl acetate extract fraction at 62.5 μg had the highest 2, 2-Diphenyl-1-picrylhydrazyl (77.87%), hydrogen peroxide (56.63%) and nitric oxide (56.28%) radical scavenging activity when compared with the ethanolic extract and other extract fractions. Flavonoids and phenols were also present in the ethanolic extract and extract fractions. The ethyl acetate extract fraction showed a higher total flavonoid content (29.9 mg quercetin equivalent/g of extract), total phenol content (47.9 mg gallic acid equivalent/g of extract) and total antioxidant capacity (35.9 mg ascorbic acid equivalent/g of extract) when compared with the ethanolic extract and other extract fractions. Conclusion: The results of this research indicated that Asparagus adscendens root ethyl acetate extract fraction have high antioxidant potentials and could be explored as a therapeutic agent for the treatment of free radical induced diseases.
 
 
 
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