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Articles by Ebru Beytut
Total Records ( 2 ) for Ebru Beytut
  Mine Erisir , Ebru Beytut , Fatih Mehmet Kandemir and Fulya Benzer
  The effects of dietary intake of vitamin E and selenium on aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities in rats treated with high doses of prednisolone were investigated. Rats were divided into 5 groups. Groups 3, 4 and 5 received a daily supplement in their drinking water of 20 mg vitamin E, 0.3 mg Se and a combination of vitamin E and Se, respectively, for 30 days. For 3 days subsequently, the control group (group 1) was given a placebo and the remaining 4 groups were injected intramuscularly with 100 mg kg-1 body weight prednisolone. After the last administration of prednisolone, 10 rats from each group were killed at 4, 8, 12, 24 and 48 h and the activities of aspartate aminotransferase and alanine aminotransferase enzymes in their tissues were measured. In the group, treated with prednisolone alone, AST activity in the liver was not affected, the ALT activity was significantly decreased at 12 h only. AST and ALT activities in the kidneys were significantly decreased by prednisolone at all time periods. AST activity in the heart also decreased in the prednisolone group between 4 and 24 h, significantly at 12 h. Significant decreases were found at 4, 8 and 12 h in the heart ALT activity of the prednisolone administered group. AST activity in the liver, kidneys and heart was lower in vitamin E and Se supplemented groups than control and prednisolone groups. In the combination group, compared to both the control and prednisolone groups, AST activity in the kidneys and heart was decreased, but increased in liver. Vitamin E and Se alone or in combination had a preventive effect on the decrease of ALT activity in the liver and kidneys caused by prednisolone. ALT activity in the heart tissue of the vitamin E supplemented group was found to be increased at all time periods, however, it reduced in the Se and combination groups compared to the prednisolone group. Therefore, the present study demonstrates that vitamin E and Se alone or in combination may prevent the decrease in ALT activity in the liver and kidneys caused by high doses of prednisolone.
  Ebru Beytut , Ozden Barim and N. Nabil Kamiloglu
  This experiment was conducted to study the effects of different levels of dietary DL-α tocopheryl acetate on Lipid Peroxidation (LPO) as Malondialdehyde (MDA) and on the antioxidant defence system in the gills, hepatopancreas and muscles of the freshwater crayfish, Astacus leptodactylus. Crayfish were fed 2% of their total wet weight with vitamin E supplemented diets or a control diet, daily for 122 days. The vitamin E contents of the control diet and of the experiment 1 (E100), 2 (E600) and 3 (E1200) diets, were 66, 100, 600 and 1200 mg kg-1, respectively, on a dry weight basis. The activities of Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GSH-Px) and levels of reduced Glutathione (GSH) and MDA were measured in the hepatopancreas, gills and muscles of the freshwater crayfish, Astacus leptodactylus. The results of the experiment indicated that vitamin E inhibited LPO at the hepatopancreas in a comparatively lower dose than in the gills and muscles. SOD activity decreased significantly in the gills and muscles of the crayfish fed with supplemented diets, but in the hepatopancreas a decrease was observed only in response to the higher doses of vitamin E (600 and 1200 mg kg-1 feed). CAT activity was reduced significantly in the gills and muscles but not in the hepatopancreas. While GSH-Px activity was significantly elevated in the hepatopancreas by vitamin E, its activity remained unaltered in the gills and muscles. The GSH content of the gills, hepatopancreas and muscles was substantially elevated in the vitamin E supplemented crayfish. Thus, the findings of the present investigation suggest that dietary vitamin E is capable of reducing LPO level and modulating the antioxidant defence system in gills, hepatopancreas and muscles. Nevertheless, the response is highly tissue specific. Moreover, the highest doses of vitamin E (600 and 1200 mg kg-1 feed) did not provide much additional protection in any of the tissues.
 
 
 
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