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Articles by E.S. Orhue
Total Records ( 2 ) for E.S. Orhue
  E.S. Orhue , M. Idu , J.E. Ataman and L.E. Ebite
  This study investigated the possible toxicity of consumption of the leaf by determining a variety of serum biochemical parameters in liver and renal function tests, haematological and physical parameters. A 5 week repeated dose toxicity of Jatropha tanjorensis leave powder was carried out in rabbits. Forty animals, male and female, were administered feed mash plus ground J. tanjorensis leaf powder in graded concentrations of 0, 5, 10 and 25%. All rabbits survived at the end of the study and results showed no significant alteration in average body weight in the treatment groups when compared with the control group. The haemoglobin, hematocrit, platelets and platelet cell distribution width in the female group, showed significant increase between the control and the treated groups. This is an indication of an improved bone marrow function. No severe histopathologic indicator was recorded.
  A.O. Akhigbe , M. Idu , E.S. Orhue , J.E. Ataman and S.O. Ehimwenman
  Toxicological study of Jatropha tanjorensis leaves was conducted by evaluating changes in weight, biochemical and ultrasonographic parameters of rabbits that have been administered varying concentrations (0, 5, 10 and 25%) of the ground leaves mixed with feed-mash for a period of 30 days. There was no significant difference (p<0.05) in weight of rabbits. Renal function tests revealed that there was a significant reduction of serum urea concentration in the male rabbits (p<0.05) from 38.33 in group C to 18.33 in group D. This suggests that the amount of J. tanjorensis plant powder used in this study could interfere positively with the filtration function of the kidney in rabbits. The ultrasound picture of kidney, heart and spleen showed no significant change from the control, where as there was reduction in the size of the liver with increased echogenicity when compared with the control. This may be an indication of hepatic toxicity.
 
 
 
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