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Articles by E.P. Sabina
Total Records ( 3 ) for E.P. Sabina
  E.P. Sabina and M. Rasool
  The aim of this research is to determine the protective efficacy of Triphala in adjuvant-induced arthritis with respect to lipid peroxidation, antioxidant status and inflammatory mediator tumour necrosis factor-alpha (TNF-α). Arthritis was induced by intradermal injection of Complete Freund’s Adjuvant (0.1 mL) into the right hind paw of Swiss albino mice. Triphala (1000 mg kg-1 day-1) and Indomethacin (3 mg kg-1 day-1) were orally administered for 8 days (from 11th to 18th day) after adjuvant injection. The levels of lipid peroxides, enzymic and non-enzymic antioxidants and tumour necrosis factor-α were measured in blood and spleen of control and arthritic animals. In arthritic animals, the lipid peroxidation and tumour necrosis factor-α were found increased, whereas a decrease in antioxidant levels was observed. These observed alterations were significantly modulated to near normal levels by oral administration of Triphala (1000 mg kg-1 day-1) in arthritic animals. The present study shows the antiarthritic effect of Triphala against adjuvant-induced arthritic mice.
  M. Rasool , E.P. Sabina , P. Nithya and K. Lavanya
  This study was intended to evaluate the analgesic, antipyretic and ulcerogenic properties of aqueous suspension of Spirulina fusiformis (400/800 mg kg-1 b.wt.-1) in different experimental standard models in mice. For comparison purpose, non-steroidal anti-inflammatory drug Indomethacin (10 mg kg-1 b.wt.-1) was used as a standard. The results showed that Spirulina fusiformis possesses significant analgesic and antipyretic effect with the absence of gastric damage at different dose levels in mice.
  E.P. Sabina and M. Rasool
  An Indian ayurvedic herbal formulation, Triphala (500/1000 kg-1 b.wt-1) was assessed for analgesic, antipyretic and ulcerogenic activities on the experimental models in mice. For comparison purpose, non-steroidal anti-inflammatory drug Indomethacin (10 mg kg-1 b.wt-1) was used as a standard. It was found that Triphala at both the dose levels produced excellent analgesic and antipyretic effect, with the absence of gastric damage. The results obtained clearly show that Triphala possesses potent analgesic, antipyretic and gastroprotective effect.
 
 
 
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