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Articles by E.O. Nwoke
Total Records ( 4 ) for E.O. Nwoke
  O.I. Iribhogbe , U. Akpamu , J.E. Emordi , A. Aigbiremolen , E.O. Nwoke and B. Idinoje
  The effect on electrolyte profile following oral administration of antioxidants (vitamin A, C and E supplements in early pregnancy was investigated using albino rats of the Wistar strain. Eighty-five female rats weighing between 255-300 g were used for the study. They were randomly assigned to three study groups having 5 sub groups with five animals each, a control and vehicle group with five animals each. After pregnancy has been confirmed, the control group was administered 1 mL of distilled water, vehicle group 1 mL of tween 80, while test groups 1, II and III received different doses of vitamin A, C and E, respectively via the intragastric route for 11 days. The administration of vitamin A, C and E in early pregnancy for 11 days produced insignificant changes in serum Na+ levels (p>0.05) and a significant increase in serum Ca2+ level. With the exception of vitamin C, vitamin A and E produce a significant increase in serum K+ and Cl¯ levels. Conclusively administration of vitamin A, C and E in early pregnancy cause no significant alteration in serum Na+ levels. However, care must be taken when vitamin A and E are administered with agents that elevate serum Ca2+ and K+ levels as this may pontentiate hypercalcemia and hyperkalemia, respectively in early pregnancy.
  O.I. Iribhogbe , A. Aigbiremolen , U. Akpamu , J.E. Emordi and E.O. Nwoke
  The purpose of this study is to evaluate the effects of vitamin A, C and E supplementation on lipid profile in early pregnancy. A total of 85 adult female wistar albino rats weighting 225-300 g were used and randomly grouped into 5 groups (2 control groups of five rats each, 3 test groups with 5 sub- groups of 5 rats each). After, pregnancy was confirmed, the control groups were administered distilled water and tween 80 respectively, while test groups A, C and E received vitamin A, C and E supplements, respectively. At the end of the 11th day of the experiment, blood samples were collected and TC (total cholesterol), TG (Triglyceride), LDL-C (low density lipoprotein cholesterol and HDL-C (high density lipoprotein cholesterol) were assayed using standard procedure. The test group had significantly increased TC, LDL- C and HDL- C but decreased TG levels following vitamin A administration when compared with control (p<0.05). The group supplemented with vitamin C also had significantly higher TC, TG and LDL- C and unchanged HDL-C compared with control (p<0.05). The group supplemented with vitamin E had a non significant TC levels, a significantly increased TG and HDL- C and a significantly reduced LDL- C levels (p<0.05). Based on results observed, we suggest that, in pregnancy, dietary supplementation with Vitamin A and E may be cardioprotective. This is because vitamin A and E significantly increase HDL- C, although this is accompanied by increase of other serum lipid component. Vitamin C, however was not beneficial.
  O.I. Iribhogbe , J.E. Emordi , E.O. Nwoke , B.O. Idonije and U. Akpamu
  The purpose of this present study is to determine the influence of varying combinations of antioxidant Vitamins on the hyper-hepatic state of pregnancy. To achieve this, seventy pregnant Wister albino rats weighing between 250-300 g were procured and grouped into 2 control groups treated with distilled water and vehicle- tween-80, respectively and three cohorts (I, II and III) with four sub-groups each (n = 5). Starting from the 7th day, group I received a varying dose combination of Vitamin A+C, group II Vitamin A+E and group III Vitamin C+E respectively for 11 days. Results of liver function assay revealed that supplementation with Vitamin A+C, A+E and C+E caused a significant reduction (p<0.05) in serum protein and a non-significant (p>0.05) alteration in serum albumin. Except for ALT where Vitamin A+E combination produced no significant alteration, serum AST (Aspartate transaminase) and ALP (Alanine transaminase) were significantly reduced (p<0.05) with antioxidant Vitamin combination therapy when compared with control. Antioxidant vitamin combination may be advantageous in pregnancy induced hyper- hepatic state. However, further study is needed in this respect.
  B.O. Idonije , E.O. Nwoke , O. Festus and O.M. Oluba
  Malaria has protean clinical manifestations and Acute Renal Failure (ARF) is one of its serious complications and could be life threatening. Information on kidney involvement in malaria in Africa is still scanty and Nigeria is no exception. Kidney function was assessed in 60 (28 males and 32 females) malaria positive patients (as test subjects) and 40 (16 males and 24 females) malaria negative individuals (as controls) using plasma creatinine, urea and uric acid as test indicators. Descriptive analysis of results obtained showed that plasma creatinine level was significantly (p<0.05) increased in both males and females malaria positive patients (tests) compared to their respective controls (malaria negative males and females, respectively). Female test subjects also had significantly higher plasma urea concentration compared to female controls. No significant change (p>0.05) was observed in plasma uric acid between female test subjects and female control subjects. Similarly, plasma urea and uric acid levels were not significantly altered in male test subjects compared to male control subjects. Males test subjects were observed to have higher plasma levels of the test parameters compared to female test subjects. Comparative study between male and female test subjects showed significantly higher concentrations in plasma creatinine and uric acid in male test subjects compared to female test subjects. From these results, it is concluded that renal impairment is a clinical feature of malaria in Ekpoma, South-South Nigeria.
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