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Articles by E.K.I. Omogbai
Total Records ( 4 ) for E.K.I. Omogbai
  M. Idu , E.K.I. Omogbai , F. Amaechina and J.E. Ataman
  The effect of the aqueous extract of the leaves of Stachytarpheta jamaicensis (L.) Vahl. on blood pressure was investigated in anaesthetized normotensive male rabbits. The extract was administered intravenously at doses ranging from 2.5-80 mg kg-1. The extract caused a dose-dependent fall in blood pressure and heart rate. 2.5 mg kg-1 of the extract reduced the Mean Arterial Pressure (MAP) from the initial 102.8±4.2 to 96.6±7.3 mmHg and the Heart Rate (HR) from 398.3±8.3 beats/min to 373.1±9.7 beats/min. 80 mg kg-1 reduced MAP and HR to 38.9±3.1 mmHg and 178.3±83.7 beats/min, respectively. Neither atropine nor promethazine inhibited the hypotensive effect of the extract. The acute hypotensive effect of the extract may be partly due to the negative chronotropic effect or to a direct effect on vascular smooth muscle.
  M. Idu , J.E. Ataman , A.O. Akhigbe , E.K.I. Omogbai , F. Amaechina and E.A. Odia
  Effect of powdered Stachytarpheta jamaicensis L. leaves known for treating different ailments was investigated for toxicity. In the study, twenty Wister rats (male and female) after due acclimatization, were fed with different graded mixtures of feed mash and the treatment plant. The animals were weighed and divided into four groups of three treatment groups and one control group with each group consisting of five rats. The rats were administered different concentrations of powdered S. jamaicensis leaves mixed with different amount of feed mash. i.e., 75, 50 and 25 g of S. jamaicensis was mixed with 25, 50 and 75 g of normal feed mash. The control was fed only with feed mash all through the period of experiment. The results revealed levels of Alkaline Phosphatase (ALP), Serum Glutamate Oxaloacetate Transaminase (SGOT) and Serum Glutamate Pyruvate Transaminase (SGPT) were slightly elevated (p>0.05). Bilirubin levels in all the groups showed slight variation (p>0.05) when compared with control. The ultrasound picture of heart, liver, kidney and spleen showed no significant difference from control. From the results obtained, no significant alteration in the normal serum biochemistry as well as in the echogenic pattern was identified between the control and experimental rats thus suggesting wide therapeutic safety margin in the use of S. jamaicensis.
  J.E. Ataman , M. Idu , E.A. Odia , E.K.I. Omogbai , F. Amaechina , A.O. Akhigbe and L.E. Ebite
  The toxicity of powdered Stachytarpheta jamaicensis (L.) Vahl. leaves, known for treating different ailments such as diabetes, hypertension and bacterial infections in some Nigerian communities, was investigated in rats. Twenty Wister rats (male and female) were fed with different graded mixtures of Pfizer feed mash and the leaf powder. The animals were weighed and divided into four groups of three treatment groups and one control group with each group consisting of five rats. The rats were administered different concentrations of powdered S. jamaicensis leaves mixed with different amount of feed mash.i.e. 75, 50 and 5 g of S. jamaicensis was mixed with 25, 50 and 75 g of normal feed mash. The control was fed only with feed mash all through the period of experiment. The results obtained showed slight variation on the physical signs/body appearance of the animals and mild histopathlogic 1esions such as congestion, fatty changes and necrosis in selective tissues such as the liver, blood vessels, kidney, lung and testis but the brain, eyes, intestines (small and large) and heart tissues were essentially normal. S. jamaicensis seem to cause mild non-dose dependent systemic toxicity in some specific tissues.
  M. Idu , E.K.I. Omogbai , G.E. Aghimien , F. Amaechina , O. Timothy and S.E. Omonigho
  he phytochemical analysis carried out on the leaves of Stachytarpheta jamaicensis showed the presence of secondary metabolites including tanins, saponins and flavonoids which have great medicinal property. Crude concentrations of aqueous extract of leaves showed varying activities on Bacillus subtillis, Escherichia coli, Candida albicans, Staphylococcus aureus, Pseudomonas aureginosa, Proteus vulgaris, Klebsiella arogene, Proteus mirabilis and J62K1 serving as control. Similar trend applied to the alcoholic extract of leaf but slight inhibition was observed on Staphyllococcus aureus and Proteus vulgaris thus indicating it’s antimicrobial effect but at high concentration. The acute toxicity of the aqueous extract on Winstar rats revealed no mortality even up to dose of 4 g kg-1 body weight and no significant changes in body weight p>0.05. Also, eye color was normal and loss of hair was absence. Thus indicating that the plant is therapeutically safe for use even at high concentration, though the chronic effect was not investigated.
 
 
 
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