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Articles by E.F. Laing
Total Records ( 2 ) for E.F. Laing
  C.A. Turpin , L. Ahenkorah , W.K.B.A. Owiredu , E.F. Laing and N. Amidu
  The aim of this study was to determine the risk factors among Ghanaian women with Pregnancy-Induced Hypertension (PIH). Thirty women with preeclampsia, seventy with gestational hypertension and fifty normotensive pregnant women (controls) in the second half of pregnancy were recruited for this study. There was a significant increase in the prevalence of metabolic syndrome among the PIH subjects as compared to the normotensive pregnant women (controls) using the National Cholesterol Education Program (NCEPIII) and World Health Organisation criteria. Ghanaian women presenting with PIH are very prone to the development of the metabolic syndrome, thus the indices must be screened for during antenatal care.
  E. Woode , N. Amidu , William K.B.A. Owiredu , E. Boakye-Gyasi , E.F. Laing , C. Ansah and M. Duwiejua
  This study has characterized the effect of an ethanolic extract of roots of Sphenocentrum jollyanum (SJE) which are chewed or taken in alcoholic bitters in Ghana for its stimulant effect on the CNS and as an aphrodisiac agent. Four widely used animal models of anxiety: the open field test, elevated plus maze, hole-board and light/dark box were employed. Results were compared qualitatively to those obtained for diazepam and caffeine which served as anxiolytic and anxiogenic drugs, respectively. Acute administration of SJE (100-1000 mg kg-1, p.o.) exhibited anxiety-like effects dose-dependently, which were qualitatively similar to those induced by caffeine (10-100 mg kg-1). Both drugs decreased the number of entries and time spent on the open arms of the elevated-plus maze and increased the number of visits to the corners of the open field. In addition, SJE decreased the number and duration of head dips compared to vehicle-treated mice. Also, the extract exhibited anxiogenic properties in hole-board and light/dark box by significantly decreasing the number of head-dips and the time spent in the dark portion of the light/dark box, respectively. In contrast, diazepam (0.1-1 mg kg-1) exhibited a typical profile of an anxiolytic drug. At all doses tested, SJE produced no motor deficits in animals using the rotarod test but decreased spontaneous locomotor activity in the activity cage apparatus. In conclusion, the results indicate that the root extract of S. jollyanum has anxiogenic like effects in mice and thus supports the use of the plant in traditional medicine.
 
 
 
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