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Articles by E.E. Iyare
Total Records ( 6 ) for E.E. Iyare
  E.E. Iyare and U.I. Nwagha
  The report that intervention during the juvenile-pubertal period in rats modifies the phenotype induced by prenatal nutrition suggests some degree of plasticity in the juvenile-pubertal period. It is not known whether consumption of aqueous extract of Hibiscus sabdariffa (HS) during the juvenile-pubertal period will affect the growth and onset of puberty in rats. The present study was therefore designed to investigate this. Weaned 21 days old rats, whose mothers were given food and water ad libitum during pregnancy and lactation, were divided randomly into three groups of nine rats each. Control group had tap water only while the extract groups had 0.6 g extract/100 mL and 1.8 g extract/100 mL as their drinking solution throughout the juvenile-pubertal period [postnatal day (PND) 21-puberty onset]. From PND 30 onwards, the rats were inspected daily for vaginal opening, which was used as the index for puberty onset. Rats in the HS groups (0.6 and 1.8 g/100 mL) drank less fluid (solution of HS extract and water) and consumed less food compared with the control group at all periods of measurement. The weight of 0.6 g/100 mL was not different from the control whereas 1.8 g/100 mL was lower at PND 28, similar at PND 35 and higher at PND 42 compared with the control. Puberty onset in the HS groups was significantly delayed compared with the control. It is concluded that consumption of aqueous extract of HS during the juvenile-pubertal period decreased fluid and food consumption, increased weight gain and delayed puberty onset in rats.
  A.N. Katchy , C.O. Iyare , B.D. Adeniyi , V.O. Okonkwo , R.I. Odama , C.O. Ezeh and E.E. Iyare
  Background and Objective: Medicinal plants constitute a fundamental component of the traditional healthcare system in rural communities throughout Africa and Gongronema latifolium (GL), is widely trusted in Nigeria to have strong nutritional and medicinal values. This study was done to determine the effect of maternal consumption of GL during lactation in young adult offspring. Materials and Methods: Twenty four female albino Wistar rats were used for this study and were randomly assigned to four (4) groups. Group I: Control, Group II, 100 mg kg–1, III, 200 mg kg–1 and IV: 400 mg kg–1 at delivery. The extract was administered orally and daily throughout lactation. Results: At postnatal day 42, offspring of extract-treated groups showed a dose-related significant decrease (p<0.05) in body weight, food intake, glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C) and a significant increase in liver weight index, pancreatic weight index, high-density lipoprotein cholesterol (HDL-C) and insulin concentrations of the offspring when compared with control in both sexes. Histological examination showed that GL extract caused histological alterations of the liver structures with various changes in the size of the sinusoids, with mild inflammatory cells without hepatotoxicity and cellular multiplication when compared with control. Conclusion: This study suggested that consumption of GL extract by lactating dams may improve metabolic homeostasis in young adult offspring.
  E.E. Iyare and F.E. Iyare
  The present study was designed to investigate whether pups exposed to aqueous extract of HS during the foetal period and during early postnatal period would have a comparable growth with control pups in accordance with the "predictive adaptive response" hypothesis. Three groups of pregnant Sprague-Dawley (SD) rats were used for this study. Group C had tap water while groups A and B had 0.6g/100ml and 1.8g/100ml HS extract respectively to drink throughout pregnancy and through 20 days postpartum. All groups had normal rat chow ad libitum. Dam weights were recorded daily throughout pregnancy and through 20 days postpartum while pup weights were recorded at birth, 10 days, 14 days and 20 days postpartum. Results of the present study show no statistically significant difference (p>0.05) in the growth of pups at 10, 14 and 20 days postpartum in all groups except for group B pups whose growth was lower (p<0.05) at 20 days postpartum. We conclude that prenatal and early postnatal exposure to an aqueous extract of Hibiscus Sabdariffa does not appear to affect early postnatal growth in Sprague-Dawley rats.
  E.E. Iyare and U.I. Nwagha
  This study investigated whether consumption of aqueous extract of Hibiscus sabdariffa during the juvenile-pubertal period will affect the BMI and visceral organ weights at onset of puberty in rats. Weaned 21 days old rats, whose mothers were given food and water ad libitum during pregnancy and lactation, were divided randomly into three groups of nine rats each. Control group had tap water only while the extract groups had 0.6 g-extract/100 ml and 1.8 g-extract/100 ml as their drinking solution throughout the juvenile-pubertal period (PND 21-puberty onset). All groups had normal rat chow and their respective drinking solutions ad libitum. From PND 30 onwards, the rats were inspected daily for vaginal opening, which was used as the index for puberty onset. Rats in the extract groups (0.6 g/100 ml and 1.8 g/100 ml) drank less fluid and consumed less food compared with the control group at all periods of measurement. The weight of 0.6 g/100 ml was not different from the control whereas 1.8 g/100 ml was lower at PND 28, similar at PND 35 and higher at PND 42 and at puberty onset compared with the control. Puberty onset in the extract groups was delayed and body weights and lengths, BMI, visceral organs weights and weight indices were higher in the extract groups. It is concluded that consumption of aqueous extract of Hibiscus sabdariffa during the juvenile-pubertal period decreased fluid and food consumption, increased BMI and visceral organs’ weights and may predispose to obesity at puberty onset in rats.
  E.E. Iyare and O.A. Adegoke
  The present study was designed to investigate the effect of consumption of aqueous extract of Hibiscus sabdariffa (HS) during pregnancy on fluid and food intake, weight gain during pregnancy, length of gestation, litter size and birth weight. Eighteen in-bred virgin female Sprague-Dawley rats aged between 10-12 weeks and weighing 125 ± 5.5g (mean ± SEM) with two consecutive regular 4-day estrus cycle were used for this study. These rats were randomly assigned to one of three groups on gestational day one. Group A (control) were given tap water to drink throughout pregnancy, while groups B and C were given 0.6g-extract/100ml and 1.8g-extract/100ml respectively to drink throughout pregnancy. All groups had normal rat chow and their respective drinking solution ad libitum. Mean fluid and food intake and total pregnancy weight gain were significantly reduced in the HS group. There was no significant difference in length of gestation among the various groups but there was a significant reduction in litter size and a significant increase in litter birth weight in HS groups (B and C) compared with control group (A). There were no apparent malformations at birth.
  E.E. Iyare and O.A. Adegoke
  The present study aimed to investigate whether or not maternal consumption of aqueous extract of Hibiscus sabdariffa (HS) during lactation has any effect on the body weight and body mass index at onset of puberty in the female offspring. Eighteen in-bred virgin female Sprague-Dawley rats aged between 10-12 weeks and weighing 125±5.5g (mean±SEM) with two consecutive regular 4-day estrus cycle were used for this study. On the day of delivery, the dams and their pups were randomly assigned to one of three groups of 6 rats/group. One group had tap water (control), another had 0.6g-HSextract/100ml in their drinking water while the third group had 1.8g-HSextract/100ml in their drinking throughout lactation. Results showed that maternal consumption of aqueous extract of HS during lactation at the doses tested, delayed onset of puberty and elevated body weight and body mass index at onset of puberty in female offspring.
 
 
 
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