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Articles by E.C.C. Udenze
Total Records ( 2 ) for E.C.C. Udenze
  E.C.C. Udenze , A.U. Ezirim , C.P. Ihedimbu and C.I. Iheme
  The effects of oral administration of Garcinia kola seeds on haematological and defence parameters of diabetic rats were investigated. Thirty acclimatized wistar rats weighing between 240-250 g were divided into six groups of five animals per group (n = 5). The first two groups of rats; non-diabetic control and non-diabetic treated groups orally received normal saline and 600 mg kg-1 b.wt. of Garcinia kola seed powder (GKP), respectively. The last four groups which were made diabetic by intra-peritoneal injection of alloxan monohydrate had one diabetic control that orally received normal saline and three diabetic groups that got 300, 600, 900 mg kg-1 b.wt. of GKP. The GKP was then given twice daily for 21 days after which the animals were sacrificed, blood collected by cardiac puncture for glucose and haematological analysis. Results showed that GKP significantly reduced blood glucose, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration and lymphocyte of diabetic rats. It significantly increased RBC, WBC, PCV, neutrophil and monocyte of diabetic treated rats. This study therefore depicts GKP as a hypoglycaemic agent with potential to normalize aberrant haematological and defence parameters associated with diabetes.
  E.C.C. Udenze , V.B. Braide , C.N. Okwesilieze and G.C. Akuodor
  Objective: The pharmacological effects of Garcinia kola seed Powder (GKP) on blood sugar, lipid profile and atherogenic index of diabetic rats were studied. Materials and Methods: Thirty male albino Wistar rats were divided into six groups of five animals per group. The first two groups: non-diabetic control and non-diabetic treated were normal animals and orally given normal saline and 600 mg kg-1 b.wt. GKP respectively. The last four groups which were made diabetic using alloxan monohydrate had one diabetic untreated group, that received normal saline and three diabetic treated groups which received 300, 600 and 900 mg kg-1 b.wt. of GKP orally, respectively. At a single dose of treatment, blood was collected through tail vein puncture and blood glucose concentration measured with glucometer at 0, 2, 4, 6 and 8 h after which it was continued for 21 days. At the end of the treatment period, the animals were sacrificed and blood collected via cardiac puncture from where serum was recovered for lipid profile analysis. Results: GKP treatment significantly lowered blood glucose and improved lipid profile and atherogenic index of diabetic rats. This investigation therefore portrays GKP as an antidiabetic, antilipidemic and anti-atherogenic agent with a tremendous potential to protect against coronary heart disease.
 
 
 
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