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Articles by E.A. Balogun
Total Records ( 2 ) for E.A. Balogun
  R.O. Arise , A.A. Akintola , J.B. Olarinoye and E.A. Balogun
  The study was carried out to investigate effects of administration of aqueous extract of Nauclea latifolia stem on lipid profile and some liver and kidney parameters of rat. Thirty rats were grouped into five. Each group consisting of six rats each. Group 1 served as the control and was administered 2 mL distilled water. The remaining groups were administered 200, 400, 600 and 800 mg kg-1 b.wt. of aqueous extract of Nauclea latifolia stem, respectively. Administration lasted for twenty eight days during which three rats from each group were sacrificed twenty four hours after administration on the fourteenth day and the remaining, twenty eighth day. Liver, kidney and blood were collected and alkaline phosphatase, alanine aminotransferase, aspartate amino transferase, urea, creatinine, malondialdehyde level as well as lipid profile evaluated. The results showed a significant (p<0.05) concentration dependent decrease in total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) and increase in low density lipoprotein cholesterol (LDL-C) and triglycerides (TG) at both periods. Similar results were obtained in serum concentration of creatinine and urea with TC and HDL-C. There was significant concentration dependent reduction (p<0.05) in liver and kidney alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase activities with a corresponding significant increase (p<0.05) in their serum activities. This revealed a time and concentration dependent hepatotoxic and nephrotoxic potentials of the aqueous extract of Nauclea latifolia stem.
  J.O. Adebayo , A.H. Zailani and E.A. Balogun
  The effects of daily oral administration of ethanolic extract of Clerodendrum violaceum leaves (13 mg kg-1 body weight) for 5 days on some liver function indices of Plasmodium berghei-infected mice were investigated. The evaluations were done on days 3, 8 and 14 post-infection. The indices studied include serum albumin, globulin, total protein, total bilirubin and conjugated bilirubin concentrations with the specific activities of Glutamate Pyruvate Transaminase (GPT), Glutamate Oxaloacetate Transaminase (GOT), Alkaline Phosphatase (ALP) and γ-Glutamyl Transferase (GGT) in the liver and serum. Treatment of infected mice with extract was able to significantly (p<0.05) ameliorate the alterations in all the parameters observed in infected untreated mice, comparing favourably with chloroquine treatment. Administration of extract to uninfected mice showed no significant effect (p>0.05) on the parameters studied both in the serum and liver compared to the uninfected untreated control, except that it significantly increased (p<0.05) liver GPT activity. The results of this study suggest that the ethanolic extract of Clerodendrum violaceum leaves is able to considerably reverse the alterations caused by malaria infection in all parameters studied and is relatively non-toxic. Further studies on Clerodendrum violaceum as a source of antimalarial remedy are indicated on the basis of these results.
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