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Articles by E.A. Ashamu
Total Records ( 2 ) for E.A. Ashamu
  W.A. Saka , R.E. Akhigbe , O.S. Ishola , E.A. Ashamu , O.T. Olayemi and G.E. Adeleke
  There is a lack of reliable hepatotherapeutic drugs in modern medicine in the management of alcohol/drug-induced liver damage. Aloe vera extract has been used in folklore medicine for its medicinal values. This study evaluates the hepatotherapeutic activity of aqueous extract of Aloe vera gel in rats. Sprague-Dawley rats were divided into three groups; the negative control, positive control and the extract-treated groups. The negative control received only distilled water daily. The positive control received alcohol, while the extract-treated group received aqueous extract of Aloe vera and alcohol. Hepatotoxicity was induced in the positive control and extract-treated rats with alcohol. The hepatotherapeutic effect was evaluated by performing an assay of the serum total bilirubin, alkaline phosphatase, aspartate and alanine transaminases and liver histopathology. Alanine transaminase activities were comparable in all groups. Alcohol treatment alone significantly (p<0.05) increased total serum bilirubin, alkaline phosphatase and aspartate transaminase activities. Alcohol-induced hepatic dysfunction was abrogated by Aloe vera extract. Histopathological examination revealed that alcohol induced hepatic damage. Aloe vera treatment maintained hepatic architecture similar to that seen in the control. This study shows that aqueous extract of Aloe vera gel is hepatotherapeutic and thus lends credence to the use of the plant in folklore medicine in the management of alcohol-induced hepatic dysfunction.
  P.B. Fakunle , A.J. Ajibade , L.O. Ehigie , O.A. Alamu and E.A. Ashamu
  Alcohol abuse and misuse has been widely reported to impair vision with majority of information available implicating the retina but with very scanty literature laying emphasis on the visual relay centers. Hence, some effects of chronic administration of ethanol was studied on the neuronal cells population in the visual relay centers Lateral Geniculate Body (LGB) and Superior Colliculus (SC) of 40 adult Wistar rats of both sexes grouped into treatments T1 and T2 and controls C1 and C2. The treatment groups received 25% ethanol in 2% sucrose (ad libitum) for 6 weeks except T2 animals that were made to undergo an additional 2 weeks of ethanol withdrawal period while the control groups C1 and C2 received tap water and 2% sucrose solution, respectively for 6 weeks. At the end of administration, the animals were sacrificed and process for routine histological techniques and stained for nissl substances. Body weight loss was significantly (p<0.05) observed as well as significantly (p<0.05) reduced neuronal cells population of 47 and 40% for LGB and 42 and 38% for SC neuronal loss, respectively in treatment groups T1 and T2 compared to control group. Hence, these alterations may again underline visual imbalance associated with the malfunctioning of the visual relay center most especially in the maintenance of saccade and recoding of visual signals which are postretinal related functions.
 
 
 
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