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Articles by E.A. El-Sayed
Total Records ( 2 ) for E.A. El-Sayed
  A.M. Attallah , N.A. Al-Ghawalby , A.A.F. Abdel Aziz , E.A. El-Sayed , A.A. Tabll and A.M. El-Waseef
  Evaluation of single and combined testing of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9), carbohydrate antigen (CA 242) and alphafetoprotein (AFP) in serum for diagnosis of gastrointestinal tumors were aimed in the present study. Sera of 28 healthy individuals and 181 patients with gastrointestinal tumors including colorectal cancer (n=50), pancreatic cancer (n=27), hepatocellular carcinoma (n=86), gastric cancer (n=18) were evaluated for different tumor markers. Complete liver functions were also determined. In colorectal cancer patients, single determination of CEA or CA 242 showed the highest sensitivity (48%) and combined determination improved the sensitivity to 72%. In pancreatic cancer patients, the combination of CA 19-9 with CA 242 did not increase the sensitivity above that (70.4%) of CA 19-9 alone. In HCC, AFP was the highly sensitive tumor marker. In addition, a significant positive correlation (r=0.816) was found between AFP and ALT in HCC patients. All evaluated tumor markers showed lower sensitivities (< 22%) for gastric cancer. Combined detection of CEA and CA 242 improved the sensitivity in colon cancer. CA 19-9 showed the best sensitivity for pancreatic cancer. AFP was the most sensitive tumour marker for HCC. None of the evaluated tumour markers had sufficient sensitivity to be taken as a marker for gastric carcinoma.
  S.M. Ezzat , E.A. El-Sayed , M.I. Abou El-Hawa and A.A. Ismaiel
  Nine species of bacteria were tested for sensitivity against Penicillic Acid (PA) using a disc diffusion assay. Among the tested bacterial species, Salmonella typhi appeared to be the most sensitive bacteria. Bacillus cereus showed the less response to the inhibitory effect of PA. The response of treated cells of S. typhi and B. cereus to PA was detected using light and electron microscopic examination. PA induced the formation of flattened and filamentous cells due to increase in lengths and widths of cells. This was more clear in treated cells of S. typhi than those of B. cereus. The cell wall and cytoplasmic membrane of S. typhi appeared to be damaged and a part of cytoplasmic material may be released through cracks. Moreover, deformation in the submicroscopic structure of S. typhi cells that treated with PA have been observed and some cells showed an irregularity in shape. Examination of the ultrathin sections of the treated B. cereus cells with PA, indicated that mature stainable sporangial formation in most cells and developmental stages of sporulation are obtained at a faster rate compared with those of growing vegetative control cells. Studying the antibacterial activities of PA were extended to show bacteria that resistant to some conventional antibiotics, were being sensitive to the saturated antibiotic discs with PA.
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