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Articles by E. Torlone
Total Records ( 2 ) for E. Torlone
  G. Di Cianni , E. Torlone , C. Lencioni , M. Bonomo , A. Di Benedetto , A. Napoli , E. Vitacolonna , D. Manninoss and A. Lapolla

Aims  Insulin glargine (IG), with its non-peaking action profile, might be useful in diabetic pregnancy. However, data on its safety are limited and its use during pregnancy is not recommended. This study focused on the effects of IG on perinatal outcome, particularly to estimate the rate of congenital anomalies and birthweight.

Methods  This retrospective study included women with pre-gestational diabetes who used IG before (at least 1 month) and during pregnancy. For all women we recorded data regarding maternal glycaemic control and pregnancy outcome. We also compared women treated with IG throughout pregnancy and women who stopped taking IG at an earlier stage.

Results  From 27 centres, 107 Type 1 diabetic pregnancies were identified. IG was started 10.3 ± 6.9 months before conception and in 57.4% of cases was stopped during the first trimester; 42.6% of women continued using it until the end of pregnancy. There were six abortions (four spontaneous and two induced) and five newborns (4.9%) with congenital anomalies. Glycaemic control, birthweight and the prevalence of macrosomia and neonatal morbidity were similar in women who used IG for the full term compared with those who stopped IG earlier during pregnancy.

Conclusions  This study, although limited, suggests that IG is safe and effective; the rate of congenital malformations was within the range expected for diabetic pregnancies treated with more traditional forms of insulin. IG used throughout pregnancy did not seem to influence birthweight or increase adverse outcomes.

  A. Lapolla , G. Di Cianni , D. Bruttomesso , M. G. Dalfra , R. Fresa , G. Mello , A. Napoli , T. Romanelli , L. Sciacca , G. Stefanelli , E. Torlone and D. Mannino
  Not available
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