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Articles by E. Sovia
Total Records ( 2 ) for E. Sovia
  E. Sovia , E.Y. Sukandar , J.I. Sigit and L.D.N. Sasongko
  Turmeric and garlic have been known to have antibiabetes effect. Therefore, both can be used as an alternative therapy in the treatment of diabetes. However, their mechanism of action in lowering blood glucose is still unknown. In this study, we investigated the effect of curcuminoid, S-methyl cysteine and its combination on blood glucose level and improvement of pancreatic damage in alloxan induced diabetes mice. Curcuminoid, S-methyl cysteine and their combination were given for 21 days. Then, blood glucose levels were measured and mice were sacrificed and pancreas were isolated for immunohistochemical analysis. The results showed a significant difference of blood glucose levels between control group with treatment group. Adminstration of curcuminoid, S-methyl cysteine and its combination can lower blood glucose levels significantly. Immunohistochemical analysis of pancreas showed a darker color intensity in the group given by curcuminoid and S-methyl cysteine compared with the control group. While the group given by its combination showed minor change compared with the control group. In conclusion curcuminoid, S-methyl cysteine and its combination can lower blood glucose levels. Curcuminoid and S-methyl cysteine could repair damage of pancreas caused by the induction of alloxan while its combination showed only a minor improvement.
  E.R. Yuslianti , I.P.R. Sabirin and E. Sovia
  This study was proposed to find the beneficence of noni (Morinda citrifolia L.) leaves ethanol extract as a treatment for wound healing in rat skin. This experimental study was done by making excisional wound on the back of Wistar rats then divided them into four groups which were given topical treatments of noni extract; control group treated by base gel and three treatment groups were given 10% (w/w) povidone iodine, 10% ethanol extract gel of noni leaves and 20% (w/w) ethanol extract gel of noni leaves, recpectively. The result of this study showed that 10% topical morinda ethanol extract gel (10 mg mL-1) had a significant effect on rat skin excisional wound healing compared to 10% povidone iodine (p<0.05). The level of plasma MDA of rats in every group was also examined, however there was no significant difference between treatment and control groups. This research showed that noni extract could improved excisional woung healing.
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