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Articles by E. Rajamanickam
Total Records ( 2 ) for E. Rajamanickam
  E. Rajamanickam , S. Gurudeeban , K. Satyavani and T. Ramanathan
  The leading cause of liver cancer is viral infection with hepatitis B and C virus. Liver cancer usually forms inflammation and cirrhosis caused by these viruses. The aim of the study was to investigate anti-liver cancer potential of Acanthus ilicifolius. Powdered leave material was extracted with ethanol and evaluated their anticancer potential on hepatocellular carcinoma cells (HepG2). Treatment with ethanolic extract of A. ilicofolius (AIEE) posses significant changes in cytotoxicity, apoptosis and caspase 3 expressions in HepG2 cells. The results indicated 100 μg mL-1 of AIEE reduced the viability of HepG2 cells in a dose-dependent manner, elevated lactase dehydrogenase and observed condensed chromatin, crooked vesicle shaped membrane in apoptotic nuclei and dead cells appeared bright orange. The expression of caspase 3 was decreased. This study demonstrates the A. ilicofolius have a potent anticancer source. Further analytical studies will be exploring the active constituents in holy mangrove.
  E. Rajamanickam , S. Gurudeeban , K. Satyavani and T. Ramanathan
  Acanthus ilicifolius (Acanthaceae) has received considerable attention due to its wide range of traditional usage in Indian system of medicine. The chemopreventive effect of ethanol extracts of Acanthus ilicifolius (AIEE) on N-nitrosodiethylamine (DEN, 200 mg kg–1)-induced experimental liver tumour was investigated in male Wistar rats. Experimental rats were orally treated with AIEE (400 mg kg–1 b.wt.) for 1 week before the injection of diethyl nitrosamine and continued to be 14 weeks. The changes of lipid peroxidation, antioxidants and membrane bound enzymes were studied in AIEE treated experimental and control rats. The result indicates AIEE treatment effectively suppressed liver tumour induced with DEN as revealed by decrease in the levels of extend of alanine transaminase, aspartate transaminase, alkaline phosphatase, lipid peroxidase, glutathione peroxidase and glutathione-S-transferase with a concomitant increase in enzymatic antioxidant (superoxide dismutase and catalase) levels when compared to those in liver tumour bearing rats. The result of the study concludes significant chemopreventive effect of AIEE against DEN induced liver tumour.
 
 
 
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