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Articles by E. Morales
Total Records ( 3 ) for E. Morales
  A Rojas , H Figueroa and E. Morales

The receptor for advanced glycation end products (RAGE), firstly described in 1992, is a single-transmembrane and multiligand member of the immunoglobulin protein family. RAGE engagement produces activation of multiple intracellular signaling mechanisms involved in several inflammation-associated clinical entities, such as diabetes, cancer, renal and heart failures, as well as neurodegenerative diseases. Although RAGE expression has been extensively reported in many cancer types, it is now emerging as a relevant element that can continuously fuel an inflammatory milieu at the tumor microenvironment, thus changing our perception of its contribution to cancer biology. In this review, we will discuss the role of multiligand/RAGE axis, particularly at the multicellular cross talk established in the inflammatory tumor microenvironment. A better understanding of its contribution may provide new targets for tumor management and risk assessment.

  J .L. Vicente , C. Lopez , E. Avila , E. Morales , B. M. Hargis and G. Tellez
  This study evaluated capsaicin extracted from chili pepper and its prophylactic effect on Salmonella enteritidis (SE) experimental infection, feed conversion, egg production, egg weight and yolk pigmentation in laying hens. Dekalb hens (30/treatment) were fed for 28 days with two different levels (18 and 36 ppm) of dietary capsaicin from paprika oil. Both levels (18 and 36 ppm) of dietary capsaicin did not affect the feed conversion, egg production or egg weight. At 25 days, hens were challenged with 108 cfu mL-1 of SE. Three days after inoculation, liver and spleen were collected aseptically and cultured as a combined sample. The higher capsaicin treatment significantly decreased (p<0.05) SE organ invasion (43.44%; 13/30) when it was compared with the low capsaicin treatment (56.67%; 17/30) and control group (76.67%; 23/30). Eggs were collected on day 20 of the trial and the yolk pigmentation was measured directly with a chroma meter CR-300 (Minolta) in the CIELab scale. Both concentrations of dietary capsaicin significantly increased the deposition of red pigment on egg yolk (14.11±1.40 and 17.44±1.90) compared with control group (-1.58±2.65). The results of the present investigation suggest that the natural capsaicin, extracted from paprika seeds at 36 ppm in the diet, had a prophylactic effect on experimental SE infection in laying hens and both concentrations of capsaicin increased red pigmentation of the yolk.
  E.S. Pablo , A.L.M. Sandoval , M.R. Fernandez , E. Morales , O. Prado , G. Tellez and M.T.M. Quintero
  In the present study, eighty-four Hy-Line W36 laying hens in two experiments were distributed in 7 treatments with 3 replicates of four hens each. Each treatment, hens received 3 dipping/2 min every 48 h. Residual activity was done by counting lice one month after dipping. Treated hens with no live lice were reinfested with 20 lice and repeated during three months. In experiment one, aqueous suspensions of three plant extracts were tested as dips for control of MS lice: a) Neem (Azadirachta indica) 500 ppm; b) Ruda (Ruta graveolens) 11,700 ppm; or c) Solanacea (Ardisia solanacea) 50,000 ppm; d) Negative Control (water). After the first dipping, a significant difference (p<0.05) in the number of dead lice were observed in the hens that received Neem (84.1%) or Solanacea (98.1%), however, after the second and third dipping, all treated groups showed a significant increase in the number of dead lice compared with the control. Average after the 3 dips was: Neem (93.6%); Ruda (85.2%); Solanacea (98.2%); Control (49.1%). One month later, all 3 treated groups had 0 lice compared with 38 lice in the control group. Counts of live lice at two months after first reinfestation were: Neem (0); Ruda (1); Solanacea (43); Control (51). Counts of live lice at three months after second reinfestation were: Neem (0); Ruda (15); Solanacea (NA); Control (60). In experiment two, 3 aqueous suspensions were tested: group 1) Ruda tincture 50,000 ppm; group 2) Coumaphos 1,000 ppm; or group 3) M. anisopliae 50,000 ppm. After the first dipping, a significant difference in the number of dead lice were observed in the hens that received Coumaphos (100 %), however, no significant differences were observed between treatments after the second and third dipping Counts of live lice one month later were: group 1 (2 lice); group 2 (0 lice); group 3 (38 lice). Counts of live lice at two months after first reinfestation were: group 1 (13) and group 2 (16). The results of the present study suggest that some alternative bio-control methods for lice in laying hens are effective.
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