Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by E. Joshua Parker
Total Records ( 2 ) for E. Joshua Parker
  F.C. Nwodo Okwesili , C. Nweje-Anyalowu Paul , E. Joshua Parker and Uroko Robert Ikechukwu
  The study investigated phytochemical, antihyperglycaemic and lipid profile effects of methanol extract fraction of Ricinus comminus seeds in alloxan induced diabetic male Wistar albino rats alloxan. Eighteen mice were used for the lethal dose (LD50) study while 54 Wistar albino male rats were used for the antihyperglycaemic and lipid profile, respectively. The result of the phytochemical analysis showed the richness of the extract in important phytochemicals that could confer some health benefits. The methanol extract fraction had LD50>5000 mg kg–1 b.wt., which indicate that the extract was safe to larger extent. The baseline blood glucose concentration showed non-diabetic glucose level 105.10±4.61 mg dL–1. Diabetes was induced with alloxan monohydrate. Significant decrease (p<0.05) in blood glucose levels in the test animals were observed when compared with positive control. The extract had significant effect on the blood glucose levels and lipid profile of the treated rats closer to that of the standard drug (metformin) with the serum total cholesterol and triacylglycerol levels decreasing significantly (p<0.05) in all test groups relative to positive control. However, serum HDL showed significant increase (p<0.05) in group 4 and 5 when compared with positive control. The results of the study showed that the methanol extract fraction of Ricinus communis seeds exhibited significant antihyperglycaemic activities against alloxan induced diabetes in Wistar albino rats. It suggests that the methanol extract fraction possess bioactive compounds that when properly harnessed could help in improving the health state of diabetic patients.
  E. Joshua Parker , Nweje-Anyalowu Paul Chukwuemeka , O.F.C. Nwodo and Uroko Robert Ikechukwu
  The study investigated the effect of methanol extract of R. communis seeds on blood glucose levels, antioxidant enzymes and haematological parameters of alloxan induced male Wistar albino rats. The methanol extract had LD50 value above 5000 mg kg–1 b.wt. After alloxan induction of diabetes, a significant (p<0.05) decrease in blood glucose levels were observed in all the test groups treated with the extract, when compared with positive control (group 2). The extract treated groups showed significant (p<0.05) increase in PCV, Hb, RBC and significant decrease (p<0.05) in WBC counts, when compared with positive control, however, no significant (p<0.05) difference was observed in total serum protein. With exception of group 4, malondiadehyde concentration decreased significantly (p<0.05) in test groups relative to positive control. A concentration dependent increase in glutathione activity in extract treated groups close to metformin treated group was observed when compared with normal and positive controls respectively. At higher concentrations of the extract, superoxide dismutase activity increased significantly (p<0.05) when compared with positive control. At lower concentrations of the extract, catalase activity increased significantly (p<0.05) close to metformin treated group but decreased significantly (p<0.05) with increasing concentrations of the extract close to positive control. The results of the study showed that the methanol extract of RC possess antihyperglycaemic properties and ability to modulate activities of antioxidant enzymes. It also suggests that the extract has positive effect on the haematological parameters.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility