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Articles by Dong-Li Li
Total Records ( 2 ) for Dong-Li Li
  Min Chen , Shun Huang , Yuan-Yuan Chang , Xi Zheng , Ren-Ping Zhou , Dong-Li Li and Kun Zhang
  Background and Objective: Curcumin is a bioactive natural polyphenol, but the poor bioavailability has limited its application. To be effective as a therapeutic drug, curcumin must be combined with other drugs to improve bioavailability. The aim of the present study was to investigate the effects and mechanisms of curcumin and piperine administered individually or in combination on lipopolysaccharide (LPS)-induced neuroinflammation. Materials and Methods: Mice were treated with curcumin (100 and 200 mg kg–1, p.o.) and piperine (20 mg kg–1, p.o.) for 21 days followed by LPS (250 μg kg–1, i.p.) administration for 7 days. Results: It is found that repeat injections of LPS induced neuronal damage and increased inflammatory cytokines release, while pretreatment with curcumin reversed these changes. In addition, co-administration of piperine with curcumin potentiated their neuroprotective effects as compared to the treatment with curcumin alone. It is further examined that the molecular mechanisms by which curcumin exerts its neuroprotective effects and inhibited the Toll-like receptor 4 (TLR4)-mediated downstream signaling and effectively lowered the production of inflammatory mediators. Conclusion: These findings led us to the conclusion that the effects of curcumin on LPS-induced neuroinflammation is mediated by modulating TLR4 pathway, which is enhanced by an adjuvant, piperine.
  Dong-Li Li , Xiao-Ming Li and Bin-Gui Wang
  Seven pentacyclic triterpenoids including 3β-O-(E)-coumaroyl-15agr-hydroxy-β-amyrin (1), 15agr-hydroxy-β-amyrin (2), 3β-taraxerol (3), 3β-taraxerol formate (4), 3β-taraxerol acetate (5), 3β-O-(E)-coumaroyl-taraxerol (6), and 3β-O-(Z)-coumaroyl-taraxerol (7) were isolated and identified from the stems and twigs of the mangrove plant Rhizophora stylosa. The structures of the isolated compounds were determined by extensive analysis of their spectroscopic data. Among these metabolites, compound 1 is a new oleanane-type triterpenoid coumaroyl ester, while compound 4 is a new natural product obtained here as an isolated substance for the first time. The full spectroscopic detail of compound 4 is also reported here for the first time.
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