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Articles by Dondin Sajuthi
Total Records ( 5 ) for Dondin Sajuthi
  Iskari Ngadiarti , Clara M. Kusharto , Dodik Briawan , Sri Anna Marliyati and Dondin Sajuthi
  The relationship between fatty acid composition with levels of amyloid beta and tau proteins in the cerebrospinal fluid is not widely known. The aim of this study was to assess the influence of catfish oil (CFO) and fermented catfish oil (FCFO) on cognitive functions (biology markers) aged female cynomolgus monkey (Cynomolgus fascicularis). Twelve aged female Cynomolgus were divided into 4 groups, each were fed with atherogenic iso calory with 0.2% cholesterol and 30% E (12% w/w), 3% from soybean oil, 9% from different fat sources, beeftallow (BFT), catfish oil (CFO), fermented cat fish oil (FCFO) and soybean oil (SBO). Cerebrospinal fluid was taken through suboccipital then kept at 20°C. Cognitive biology markers which were analyzed by using Tau and Aβ42ELISA kits. Changes in level of amyloid beta, tau protein and ratio of tau protein and amyloid beta were not statistically significant in the cynomolgus group four that were fed with BFT, FCFO, CFO and SBO, despite a trend toward increased levels of amyloid beta and decreased level of the tau protein / amyloid beta ratio were found in the group given with FCFO and CFO. In summary, FCFO and CFO intake capable to improve the cognitive function based on biological biomarkers.
  Deyv Pijoh , Sri Supraptini Mansjoer , Dondin Sajuthi , Dewi Apri Astuti and Irma Herawati Suparto
  Objective: This study was conducted to develop an animal model of obesity by monitoring the phenotypes of long-tailed monkeys (Macaca fascicularis) fed a high energy diet. Methodology: Fifteen adult male Long-Tailed Monkeys (LTM) weighing between 4 and 5 kg were divided into three groups of five that received one of three diets: Diet A: A commercial monkey chow diet, Diet B: Monkey chow supplemented with egg yolk and Diet C: In which wheat was the main ingredient and beef tallow was added. Body measurements, including body weight were collected monthly. Results: The LTM fed Diet B (Egg yolk-supplemented) consumed more food compared to those fed Diet A and C. Animals in the Diet B group had significantly (p<0.01) larger waist circumference, hip circumference, chest circumference and skin fold thickness compared to the other two groups. There was a close relationship between body weight and waist circumference (r = 0.863), chest circumference (r = 0.889) and hip circumference (r = 0.890). Based on the main component analysis, LTM fed Diet B had higher rates of obesity compared to LTM fed Diet A or C. Conclusion: Body characteristics of LTM fed different diets can be used to determine the presence of obesity. The LTM can serve as a useful animal model of obesity and findings from this model can be applied to studies of obesity in humans.
  Hajrawati , Henny Nuraini , Irma Isnafia Arief and Dondin Sajuthi
  Background and Objective: The Cemba plant (Albizia lebbeckoides [DC.] Benth) is one of the members of the genus Albizia and has potential as a natural antimicrobial and antioxidant. This study was conducted to evaluate the antibacterial and antioxidant activities of the Cemba leaf extract (CLE). Materials and Methods: CLE was obtained from Cemba leaf powder macerated using aqueous ethanol (EtOH), aqueous food grade ethanol (FGEtOH) and distilled water (DW). The extract was filtered and evaporated using a vacuum rotary evaporator at 40°C until reaching 1/20 of the initial volume. The obtained filtrate was freeze-dried using a freeze-drying machine for 48 h. The obtained CLE was analysed for phytochemical compounds and measured for yield percentage, total phenolic content and total flavonoid content. The antibacterial activities of the CLEs were evaluated based on their inhibition activities against six pathogenic bacterial species using the disc diffusion method. The antioxidant activity and the antioxidant capacity of the CLEs were determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical method. Results: Phytochemical screening showed that alkaloids, flavonoids, saponins, triterpenoids and tannins were found in the CLEs extracted using several solvents. The antimicrobial assay indicated that the CLEs all had antibacterial activities against both Gram-positive and Gram-negative bacteria. The highest inhibition zone (p<0.05) was obtained in the CLE extracted by EtOH (15.16±0.56). The highest antioxidant activity was noted in the CLE extracted by EtOH, resulting in IC50 and antioxidant capacity values of 2.82±0.05 mg mL–1 and 14.72±0.14 mg VCE g–1, respectively. Conclusion: it is concluded that CLE has potential as a natural antimicrobial and antioxidant.
  Suharyanto , Henny Nuraini , Tuti Suryati , Irma Isnafia Arief and Dondin Sajuthi
  Background and Objective: Recent studies show that senduduk (Melastoma malabathricum L.) leaf extract contains phenolic compounds that could possibly be used as a food preservative. However, the study of extraction methods using edible solvents has been poorly explored. This study was conducted to investigate the impact of various maceration techniques for the extraction of senduduk leaves on antioxidant and antibacterial activity. Materials and Methods: The maceration conditions explored were distilled water (T1), distilled water with shaking (T2), ethanol 25% in distilled water (T3) and ethanol 25% in distilled water with shaking (T4). Results: The result showed that shaking application resulted in lower extract activity. The extract obtained from distilled water was not significantly different to the extract obtained from ethanol 25% in percent yield (11.69 and 9.83%, respectively), antioxidant activity (64.15 and 69.62 mg BHTE g–1, respectively) and antibacterial activity. All extracts had antibacterial activity against tested Gram-positive bacteria (Bacillus cereus, Staphylococcus aureus and Listeria monocytogenes) and Gram-negative bacterium (Pseudomonas aeruginosa). The highest zone of inhibition was pointed out by the extract obtained from distilled water (15.16, 14.88, 12.10 and 15.56 mm for B. cereus, S. aureus, L. monocytogenes and P. aeruginosa, respectively). However, the extracts had no inhibitory activity toward the Gram-negative bacteria: Escherichia coli and Salmonella Typhimurium. Conclusion: The senduduk leaf extracted using distilled water without shaking has the potential to generate an extract that can be used as an antioxidant and antibacterial agent.
  Susan Soka , Antonius Suwanto , Dondin Sajuthi and Iman Rusmana
  Tempeh is a popular Indonesian fermented food made from soybean that can be a good source of dietary fibers for human health. Dietary fibers have the ability to modulate gut microbiota composition in order to improve human health. In this study, Sprague-Dawley (SD) rats were fed a standard diet supplemented with cooked and de-hulled soybean or tempeh for 28 days. The specific bacterial groups in fecal samples were quantified using real-time polymerase chain reaction with 16S rRNA gene-targeted, group-specific primers. Populations of Bacteroidetes, Bacteroides fragilis, Firmicutes and Clostridium leptum increased when supplemented with tempeh. In addition, the ratio of Firmicutes/Bacteroidetes was lower in groups fed with either raw or cooked tempeh compared to the soybean group. Previous studies showed that obese hosts have higher ratios of Firmicutes/Bacteroidetes compared to the lean hosts. Increased Bacteroidetes populations after tempeh supplementation indicated that tempeh might modulate the composition of gut microbiota toward a healthier gut.
 
 
 
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