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Articles by Donatien Gatsing
Total Records ( 4 ) for Donatien Gatsing
  Donatien Gatsing , Christiane F.N. Nkeugouapi , Bridget F. Nji-Nkah , Jules-Roger Kuiate and Felicite M. Tchouanguep
  The antibacterial activity, bioavailability and acute toxicity of the leaf extracts of Alchornea cordifolia were evaluated. The phytochemical screening was also done. Results of the in vitro antibacterial tests showed that all but the hexane extract exhibited antibacterial activities against P. aeruginosa (MIC = 2.5 mg mL-1), E. coli (MIC = 3.75 mg mL-1), S. aureus (MIC = 5 mg mL-1) and K. pneumoniae (MIC = 10 mg mL-1). Results of the serum antimicrobial activity test against P. aeruginosa showed that with animals administered the extract, serum antimicrobial activity was observed as from 3 h 45 min for the doses 2.84 and 5.68 g kg-1, independently of the sex of animals. The peaks of serum activity (maximum activity, Amax) were obtained at 6 and 4 h (Tmax) with the doses 2.84 and 5.68 g kg-1, respectively. The area under the curve (AUC) was greater with the dose 2.84 g kg-1 than with the dose 5.68 g kg-1. Flavonoids, triterpenes, saponins, anthocyanins, steroids, polyphenols and tannins were found in the leaves of this plant. Results of the acute toxicity study of the aqueous leaf extract of A. cordifolia with mice showed that the LD50 was >32 g kg-1. The data obtained in this study suggest that the leaves of A. cordifolia contain antibacterial principle(s) which are biologically available and which may not be toxic. However, at doses ≥4 g kg-1, this extract may have a depressant or sedative effect on the central nervous system, may reduce the pain perception and may induce loss of body weight.
  Paul K. Lunga , Joseph M.M. Nkodo , Jean D. Tamokou , Jules-Roger Kuiate , Donatien Gatsing and Joseph Tchoumboue
  Background and Objective: Paullinia pinnata is an African woody vine whose leaf decoction has been used in Cameroon for the treatment of bacterial infections like typhoid fever, syphilis, gonorrhea, diarrhoea and symptoms such as stomach-ache and waist pain. The present study was designed to evaluate the adverse side effects resulting from the use of P. pinnata methanol leaf extract in the treatment of Salmonella typhimurium-induced typhoid in Wistar rats. Methodology: After the establishment of infection by oral administration of a S. typhimurium suspension, animals were treated by the daily administration of P. pinnata methanol leaf extract at various doses (55.75, 111.50, 223 and 446 mg kg-1 b.wt.). The effect of the extract on body weight evolution was monitored daily. Results: Also, the effect of the extract on relative organ weight, biochemical parameters as well as liver histology was assessed. Irrespective of sex, typhoid fever induced an abnormal increase in the relative weight of most vital organs of toxicological importance. However, extract treatment normalized the excessive increase in relative organ weights; while inducing a significant (p<0.05) body weight gain in a dose-dependent manner. The level of liver enzymes (ALT and AST) were significantly (p<0.05) reduced after the treatment of the animals with P. pinnata leaf extract. The histopathological analysis of the liver revealed that extract treatment greatly reduced the degree of liver affections in a dose-dependent manner. However, at high doses (dose ≥223 mg kg-1 b.wt.) the extract was capable of stimulating hepatic necrosis. Conclusion: The overall results of this study indicate that the methanolic extract of P. pinnata leaves has hepatoprotective effects especially in males. It has adverse side effects at high doses and even at low doses in female rats and thus, should be used with caution in male and should probably be eliminated from the treatment of female subjects.
  Donatien Gatsing and Godwin I. Adoga
  Aqueous extracts of the various parts (i.e., flowers, leaves, barks and roots) of Cassia petersiana (Caesalpiniaceae) were tested for antibacterial activity against Salmonella typhi, Salmonella paratyphi A and Salmonella paratyphi B using both agar diffusion and broth dilution techniques. Phytochemical screening was also performed using standard methods. All the parts tested (at 30 mg mL-1) showed antibacterial activity against all the three bacteria strains, with the diameters of zones of inhibition ranging form 7 to 19 mm. The leaves showed the highest activity, followed by the flowers, the roots and then the barks. The MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bacterial Concentration) values of the leaf extract (i.e., the most potent extract) were 1.0 and 8.0 mg mL-1, respectively, against all the three bacterial strains. Phytochemical screening gave evidence of the presence of compounds of biological interest (i.e., alkaloids, flavonoids, cardiac glycosides, antraquinones, anthocyanins, polyphenols, triterpenes, steroids, saponins, tannins and phlobatannins) in the various part of Cassia pertersiana. Anthraquinones and phlobatannins were present only in the leaf extract. These results suggest that the leaf extract may be much more recommended to the users of C. petersiana parts in the treatment of typhoid and paratyphoid fevers.
  Donatien Gatsing , H. Ibrahim Garba , Roseline Aliyu , H. Abiodun Adebayo , P. Obekpa and I. Godwin Adoga
  The serum levels of some lysosomal enzymes-namely β-glucuronidase (EC 3.2.1.31), β-galactosidase (EC 3.2.1.23) and acid phosphatase (EC 3.1.3.2)-were measured in controls, pre-operative and post-operative nephroblastoma patients. β-glucuronidase activity showed a significant (p<0.05) increase before surgical intervention, followed by significant (p<0.05) decreases 24 h, 72 h and 7 days after operation. The activities of β-galactosidase and acid phosphatase showed no significant (p>0.05) changes before and after surgical intervention. These data indicate that nephroblastoma and surgery may have a marked effect on the serum levels of some lysosomal enzymes.
 
 
 
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