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Articles by Doha Abdou Mohamed
Total Records ( 3 ) for Doha Abdou Mohamed
  Nagwa Mohammed Ammar , Seham Salah El-Din El-Hawary , Doha Abdou Mohamed , Manal Shafik Afifi , Dina Magdy Ghanem and Gamal Awad
  Background and Objective: The genus Tribulus of the Zygophyllaceae family comprises several species which grow as shrubs or herbs in subtropical areas around the world. Phytochemical and biological studies of the different successive extracts of the aerial parts of Tribulus terrestris L. (Family Zygophyllaceae), growing in Egypt as well as the isolation and identification of the biologically active natural fractions or compounds were carried out. Methodology: The volatile constituents were prepared and analyzed by GC/MS. The lipoidal matter was prepared and analyzed by GLC. The carbohydrate and the amino acid contents were prepared and analyzed by HPLC. Saponin fraction was prepared. The activities of polar, non-polar extracts and saponin fraction as aphrodisiac, antimicrobial, cytotoxic and antioxidant were evaluated. Results: GC/MS of volatile constituents revealed the presence of thirty two compounds. The major compound was methyl linolenate (18.56%). The major fatty acid in the lipoidal matter is heptadecanoic acid (33.56%). HPLC analysis of carbohydrate and amino acid revealed the presence of inulin (5.61%) and glutamic acid (2.85%), respectively. Saponin yield was 7.38%. The results of the biological investigation of the polar and non-polar extracts revealed their aphrodisiac, antimicrobial, cytotoxic and antioxidant activities with different percentages. Phytochemical examination of the aqueous methanolic biologically active extract by HPLC revealed the presence of phenolic and flavonoid contents (11.16 and 6.076%) respectively as well as saponin. Isolation and identification of rutin, quercetin and diosgenin were carried out using several chromatographic and spectroscopic analysis. Conclusion: The herb under investigation revealed potent and remarkable biological activities due to the presence of different active constituents.
  Doha Abdou Mohamed , Ibrahim Mohamed Hamed and Karem Aly Fouda
  Background and Objective: Diabetes is a metabolic disease associated with hyperglycemia. Diabetes is the major cause of morbidity and mortality worldwide. Chronic hyperglycemia in diabetic patients leads to damage and dysfunction of many organs. The aim of the present research was studying the anti-diabetic potential of crude ethanol extract of cumin seeds (CEEC). Methods: CEEC was prepared. Diabetes was induced in rats by single dose of streptozotocin (STZ). Total flavonoids and total phenolic contents were determined in the CEEC. Free radical scavenging activity of the extract was estimated using DPPH method. Acute toxicity of the CEEC on mice was determined. The effect of CEEC on glucose tolerance was evaluated. Results: The results revealed that total phenolic and total flavonoids were presence in the CEEC by 23.02±0.045 mg GAE g–1 extract and 19±0.132 mg QE g–1 extract, respectively. CEEC showed free radical scavenging activity. Acute toxicity revealed that CEEC was completely safe up to 12 g kg–1 mice. Oral administration of CEEC reduced glycemic levels. CEEC significantly reduced plasma glucose levels in diabetic rats and elevate insulin levels significantly compared with diabetic control. CEEC improved plasma lipid profile, reduced oxidative stress and reduced inflammation in diabetic rats. Conclusion: Crude ethanol extract of cumin seeds may be used as alternative treatment for diabetes. The results indicated that CEEC may be very helpful in the improvement of plasma lipid profile as one of the risk factors for cardiovascular diseases and heart failure in diabetic patients.
  Sahar Youssef Al-Okbi , Doha Abdou Mohamed , Thanaa El-Sayed Hamed , Azzat Bayoumi Abd El Khalek and Shaimaa Elsayed Mohammed
  Background and Objective: Hepatorenal syndrome (HRS) is a major public health problem in which both liver and kidney dysfunctions are encountered. The present research aimed to investigate the beneficial use of micro-encapsulated probiotic alone (Bifidobacterium bifidum, Lactobacillus delbrueckii and Streptococcus thermophilus mixture) or with green tea alcohol extract in HRS model in rats. Materials and Methods: Flavonoids content and in vitro antioxidant activity of the extract were assessed. The animal experiment consisted of 4 groups; control healthy, control with HRS and two test groups with HRS and treated with either the encapsulated probiotic mixture alone or with green tea extract. After 3 weeks; urinary creatinine was determined in 24 h rat urine samples. Colonic microbiota was assessed in faeces. Plasma malondialdehyde, nitrite, C-reactive protein, creatinine, uric acid, urea and the activity of transaminases, catalase (CAT) and angiotensin-1 converting enzyme (ACE-1) were determined with calculation of creatinine clearance. Results: Results showed significant increase in all biochemical parameters of HRS control except for ACE-1, CAT and creatinine clearance that experienced significant reduction along with dysbiosis compared to healthy control. Test groups showed improvement in all biochemical parameters with superiority to probiotic-green tea extract combination. Both treatments produced significant increase in fecal B. bifidum, S. thermophilus and L. bulgaricus and reduction of Staphylococci and Coliform. The effect of probiotic-green tea extract combination was more pronounced concerning the last three. Flavonoids and antioxidant activity of the extract were 1.325±0.01 mg quercetin/g and 98±1.66%, respectively. Conclusion: Administration of micro-encapsulated probiotic with or without alcohol green tea extract exerted significant prevention of HRS in rat with superiority to probiotic-green tea extract combination.
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