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Articles by Doha A. Mohamed
Total Records ( 2 ) for Doha A. Mohamed
  Doha A. Mohamed , Eman A. Hanfy and Karem Fouda
  Background and Objective: Rheumatoid arthritis is an autoimmune disease associated with elevation of oxidative stress and inflammatory markers. The aim of the present research was evaluation of the antioxidant, anti-inflammatory and anti-arthritic activities of yarrow aerial parts (YAP). Materials and Methods: Proximate composition of YAP was assessed. Total phenolic compounds, total flavonoids, tannins and alkaloids contents of YAP were determined. Fatty acids methyl esters of petroleum ether extract of YAP were analyzed. The antioxidant activity of YAP was assessed. Acute anti-inflammatory activity of petroleum ether and ethanol extracts of YAP was evaluated. Anti-arthritic activity of ethanol extract of YAP was evaluated using adjuvant-induced arthritis (AIA) in rats. Results: Chemical compositions of YAP clarified presence of carbohydrate (58.29%), protein (10.33%), fat (3.85%), crude fibers (17.32%) and ash (3.37%). Total phenolic, total flavonoids, tannins and alkaloids were presence in YAP by 0.43±0.003 mg GAE g–1 , 0.31±0.008 mg QE g–1 , 0.96±0.006 mg and 1.52%, respectively. Ethanol extract of YAP showed free radical scavenging activity ranged from 47.8-87.8%. Fatty acids methyl esters analysis revealed that saturated and unsaturated fatty acids were presented by 50.55 and 16.16%, respectively. Linoleic acid and linolenic acid was present by 8.44 and 7.72%, respectively. Ethanol extract of YAP was promising as anti-inflammatory agent in carrageenan induced rat paw edema and xylene-induced mice ear edema. Ethanol extract of YAP possess anti-arthritic effect in AIA in rats through inhibition of swelling in arthritic rats, reduction of oxidative stress and inflammation. Conclusion: Ethanol extract of YAP showed promising antioxidant, anti-inflammatory and anti-arthritic activities. These activities may be attributed due to the presence of total phenolic, total flavonoids and tannins. Ethanol extract of YAP may be used as anti-arthritic agents in rheumatoid arthritis patients.
  Doha A. Mohamed , Sherein S. Abdelgayed , Hend A. Essa and Rasha S. Mohamed
  Background and Objective: Non-alcoholic fatty liver disease (NAFLD) is a public health problem presenting one of the most important common forms of liver diseases worldwide. This study was carried out to investigate the protective effect of two functional foods in form of bread containing purslane seeds meal and garden cress seeds against NAFLD. Materials and Methods: High fat and high cholesterol diet were used for induction of NAFLD in rats for 6 weeks. Plasma lipid profile (total cholesterol, triglycerides, high density lipoprotein-cholesterol and low-density lipoprotein-cholesterol, hepatic lipid profile (total fat, cholesterol, triglycerides), malondialdehyde (MDA), as well as liver (AST, ALT, total and direct bilirubin) and kidney (creatinine and urea) functions were assessed. Histological examination of liver tissue was carried out. Results: Results revealed that significant elevation in plasma and liver lipid profiles, MDA, liver enzymes (AST and ALT), bilirubin (total and direct) and kidney function (creatinine and urea) were observed in NAFLD control compared to normal control. Feeding rats on diet containing functional food I and II (purslane and garden cress bread, respectively) showed significant improvement in all the studied parameters with remarkable effect regards to functional food I (purslane bread). Conclusion: Purslane bread and garden cress bread as functional foods prepared in the present study prevent weight gain, improve plasma lipid profile and prevent hepatic lipid accumulation effectively in NAFLD model in rats. Also decreased lipid peroxidation, improve liver and kidney functions and possess hypoglycemic effect. Purslane bread was superior in the prevention of hepatic lipid accumulation.
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