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Articles by Dinakar Sasmal
Total Records ( 6 ) for Dinakar Sasmal
  Surendra K. Pareta , Kartik C. Patra , Papiya M. Mazumder and Dinakar Sasmal
  A wide range of plants and plant-derived products are used in folk medicine for the treatment of urolithiasis as a prophylactic agent or as curative agent. Most of them found to be effective, but still the complete mechanism of action of these herbal drugs remains to be unclear. In present review we are discussing the various mechanism of action through which phytotheraeupatic agents exert their antiurolithiatic effect. Unlike allopathic medicines which targets only one aspect of urolithiatic pathophysiology, most of plant based therapy have been shown to be effective at different stages of stone pathophysiology. Currently known herbal drugs exert their antilithogenic properties by altering the ionic composition of urine viz.; decreasing the calcium and oxalate ion concentration or increasing magnesium and citrate excretion. Most of these remedies also express diuretic activity or lithotriptic activity. Some of the herbal drugs reported to disaggregate of mucoproteins, which are actually binds the crystal to the renal cells. Some medicinal plants contain chemical compounds like Glycosaminoglycans (GAGs) which themselves possess an inhibitory effect in the crystallization of calcium oxalate. Antioxidant constituents of the plants also help in ameliorating the crystal/oxalate induced renal cell injury. Thus, antiurolithiatic activity of plants or herbal formulation may be due to synergism of their diuretic activity, crystallization inhibition along with antioxidant activity.
  Surendra K. Pareta , Kartik C. Patra , Papiya M. Mazumder and Dinakar Sasmal
  Introduction: Boerhaavia diffusa Linn. (Nyctaginaceae) is widely used in traditional Indian medicines against renal afflictions including calcium oxalate (CaOx) urolithiasis and is known for antioxidant activity. Objective: The present study was designed to investigate the ameliorating effect of aqueous extract of B. diffusa roots (BDE) in hyperoxaluric oxidative stress and renal cell injury. Material and methods: In vitro antioxidant activity of BDE was estimated in terms of total phenolic content and 1,1-diphenyl-2-picryl hydrazyl free radical scavenging activity. Wistar albino rats were given 0.75% v/v ethylene glycol in drinking water to induce chronic hyperoxaluria and simultaneously BDE was given to nephrolithiasic treated rats at the dose of 100 and 200 mg/kg b.w. orally for 28 days. Urinary volume, oxalate, serum creatinine, blood urea nitrogen (BUN), malondialdehyde (MDA) and antioxidant enzyme (SOD, CAT, GST, GPx) were evaluated. Results and discussion: BDE extract was found to posses a high total phenolic content and exhibited significant free radicals scavenging activity. Oxalate excretion significantly increased in hyperoxaluric animals as compared to control which was protected in BDE-treated animals. BDE treatment significantly reduced level of MDA and improved the activity of antioxidant enzymes followed by reduction in BUN and serum creatinine. In addition, BDE reduced the number of CaOx monohydrate crystals in the urine. Histological analysis depicted that BDE treatment inhibited deposition of CaOx crystal and renal cell damage. Conclusion: The present study reveals that antioxidant activity of BDE significantly protects against hyperoxaluric oxidative stress and renal cell injury in urolithiasis.
  Papiya Mitra Mazumder , Vivek Agarwal , Dinakar Sasmal and Paramaguru Rathinavelusamy
  Background: This study evaluated the acute and sub-chronic diuretic, saliuretic and kaliuretic effects of orally administered Methanol Extract of Barleria lupulina (MEBL) leaves in normal rats and thereby, confirm its ethno medical use. Materials and methods: Acute diuretic activity was estimated by single dose methanol extract of leaves of Barleria lupulina (200 and 400 mg kg-1 b.wt. p.o.) and furosemide (10 mg kg-1 b.wt. p.o.), duration of the study is 24 h. Sub-chronic diuretic activity was estimated by administered extract (200 and 400 mg kg-1 b.wt. p.o.) and furosemide (10 mg kg-1 b.wt. p.o.) for the period of eight days. Results: In acute study, the diuretic effect of MEBL at the higher dose i.e. 400 mg kg-1b.wt. was found to be highly significant at 1, 2, 4 and 6 h (p<0.01 vs. control). Both the doses of plant extract significantly enhanced the excretion of the Na+ and K+ versus control (p<0.01). In Sub-chronic study, both the doses of MEBL produced significant diuresis until day 3 (MEBL 200 mg kg-1 b.wt.) and day 5 (MEBL 400 mg kg-1 b.wt.). MEBL 400 mg kg-1 b.wt. increased the excretion of Na+ and K+ significantly (p<0.01 vs. control) throughout the treatment from Day 1 to 8. Conclusion: The present study confirmed the ethno pharmacological use of Barleria lupulina as a diuretic agent based up on the experimental conditions tested.
  Papiya Mitra Mazumder , Rathinavelusamy Paramaguru , Anuradha Mohanty and Dinakar Sasmal
  Background: Barleria lupulina is well recognized traditional medicine in the treatment of diabetes mellitus but no scientific data has been reported to its ethnomedical use in eye related long term complications of diabetes. Objective of the present study is to evaluate the anti-cataract activity of leaves of Barleria lupulina Lindl. along with its aldose reductase potential. Materials and Methods: Methanol extract of Barleria lupulina Lindl. (MEBL) was successively fractionate with hexane (HFBL), ethyl acetate (EFBL) and the aqueous fraction (AFBL). All the fractions and methanol extract were subjected to qualitative and quantitative phytochemical screening. In vitro antioxidant activity of the same was assessed by free radical scavenging activity using DPPH and hydrogen peroxide assay. The active ethylacetate fraction (EFBL) was further subjected to in vitro anti cataract evaluation against glucose induced cataractogenesis by using goat lenses. Results: The lenses incubated with EFBL at 200 and 400 μg mL-1 concentration seemed to retard the progression of lens opacification and showed a significant restoration of glutathione, SOD level (p<0.01) and reduced the level of TBARS (p<0.01) when compared with positive control group (glucose 55 mM). EFBL showed promising percentage inhibition of aldose reductase activity with lower IC50 value (50.118 μg mL-1). Conclusion: Hence, this study demonstrated that the EFBL possess significant anticataract, antioxidant and aldose reductase inhibition properties.
  Priya Ranjan , Papiya Mitra Mazumder , R. Parmaguru , Dinakar Sasmal , Rakesh Kumar Sinha , Yogender Aggarwal and Joyani Das
  Background and Objective: Salvia species have been used since ancient times for more than 60 different ailments. Salvia splendens shows a wide availability in Jharkh and region. According to existing literature, its hypoglycemic activity has already been established in diabetic-rodent model. Therefore, an effort has been made to further explore the efficacy of the active fraction of the plant against diabetes and diabetic neuropathy. Materials and Methods: The plant material was collected, shade dried and extracted with methanol. Ethyl acetate fraction of the methanolic extract (SSEA) was subjected to various tests for neuropathic pain assessment (Tail flick, Cold allodynia, R and all Selitto), biochemical tests (fasting blood glucose level, lipid peroxidation, reduced glutathione, catalase levels in brain), Motor Nerve Conduction Velocity (MNCV) determination and histopathological evaluation of the sciatic nerve. Results and Conclusion: There was a significant decrease in blood glucose level in animals treated with SSEA. At a dose of 400 mg kg-1, SSEA showed reduction of MDA and increase in SH and catalase levels in brain. The MNCV in diabetic rats (STZ-NA induced) treated with SSEA 200 and 400 mg kg-1 showed somewhat elevation in nerve conduction velocity as compared to that of diabetic rats. Transverse section of sciatic nerve showed changes due to diabetic nephropathy such as axonal swelling, derangement of nerve fibres which were reverted by 400 mg kg-1 of SSEA.
  Deepak Divakar , Dinakar Sasmal , Anoop Kumar , Abhishek Kumar and Neelima Sharma
  Background: Over the years, pyrethroids, including allethrin, are widely used for domestic and agricultural purposes and are found to be neurotoxic. However, effects on hematological and biochemical parametersare not elucidated. Thus, the first objective of the present study was to investigate the effect of allethrin on the hematological and biochemical parameters of Swiss albino mice. Further, for the amelioration of its effect, two different bioactive herbal extracts piperine (alkaloid) and curcumin (polyphenols) were evaluated. Methods: Animals were divided into six groups; the first group was used as a control. Groups 2, 3, 4, 5 and 6 were orally treated with allethrin (15 mg kg-1 b.wt.), allethrin+curcumin (100 mg kg-1 b.wt.), allethrin+piperine (100 mg kg-1 b.wt.), piperine (100 mg kg-1 b.wt.) and curcumin (100 mg kg-1 b.wt.), respectively for 28 days. Results: Administration of allethrin brought about a significant decrease in leukocytes, polymorphs, serum albumin, HDL, glucose and CPK and whereas, lymphocytes, haemoglobin, ALT, AST, serum creatinine, blood urea, total cholesterol, LDL, VLDL, triglycerides was found to be significantly increased following allethrin treatment. Gravimetric indices (body weight and organ weight) slightly declined following allethrin treatment. Further, the histopathological observations in allethrin treated mice showed the damage in all vital organs (kidney, liver, lungs, brain and heart) of Swiss albino mice. Administration of piperine and curcumin exhibited signi cant reversal of allethrin altered hematological and biochemical parameters. ALT, AST, serum creatinine, blood urea, serum albumin, HDL, glucose found to be comparable to that of the control group after piperine and curcumin administration. The presence of piperine and curcumin with allethrin preserved the normal histological architecture of the liver, kidney, lungs, brain and heart. Conclusion: These results indicate that piperine and curcumin can be a potent protective agent against allethrinalteredbiochemical and hematological alterations in mice.
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