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Articles by Dina Keumala Sari
Total Records ( 5 ) for Dina Keumala Sari
  Dina Keumala Sari , Marianne , Sri Lestari and Lidya Imelda Laksmi
  Background and Objectives: Passion fruit (Passiflora edulis Sims) seeds contain antioxidants and are expected to decrease the levels of cholesterol and malondialdehyde (MDA). The purpose of this study was to identify the effects of a passion fruit seed ethanol extract on Wistar rats fed atherogenic feed. Materials and Methods: The method of this study was a preclinical trial (post-test control group design) in rats by administering passion fruit seed ethanol extract for 14 days, using 26 male rats (Rattus norvegicus) aged two months, divided into 5 groups. The groups were a negative control group (atherogenic feed), a positive control group (standard feed) and test groups that were given the passion fruit seed ethanol extract at doses of 5 mg kg–1 body weight (BW), 10 mg kg–1 BW, or 20 mg kg–1 BW for 14 days to the Wistar rats fed with atherogenic feed. Results: The study results showed a significant difference in MDA levels, which was found in the group that was given passion fruit seed extract(10 mg kg–1 BW)and the positive control group that was given standard feed (mean±standard deviation: 1.83±0.40 mM vs 1.38±0.12 mM; p = 0.002). The level of total cholesterol also showed a significant difference, which was found in the group that was given passion fruit seed extract (10 mg kg–1 BW) with a negative control group that was given atherogenic feed (mean±standard deviation: 84.54±13.69 mg dL–1 vs 68.04±6.17 mg dL–1; p = 0.003). Conclusion: Administration of passion fruit seed extract showed a significant difference in the level of triglycerides, which was found in the negative control group that was given atherogenic feed compared with the group that was given passion fruit seed extract at a dose of 5 mg kg–1 BW (mean±standard deviation: 1.09±0.30 mg dL–1 vs 0.77±0.25 mg dL–1; p = 0.048).
  Dina Keumala Sari and Marianne
  Background and Objective: Adolescent malnutrition will determine a person’s nutritional status in adulthood. Factors that determine whether a person will develop obesity or malnutrition will persist well into adulthood. Breakfast is a full meal that is consumed in the morning. It is recommended to consume meals that are low in fat content and have a sufficient amount of carbohydrates and protein. This study aimed to evaluate the impact of consuming a full breakfast for 6 days on the nutritional status and knowledge of breakfast among junior high school students. Materials and Methods: We recruited a total of 68 students from the 7th, 8th and 9th grades at Al Washliyah 42 Junior High School in Berastagi, North Sumatera, Indonesia. These students were given breakfast for 6 days in a row with counselling on the importance of breakfast via the “Breakfast Ambassador” programme. Breakfast was served by the school catering service and supervised by five ambassadors. Participants were asked to complete a questionnaire before and after the study. Nutritional status and knowledge of breakfast and a balanced diet were also assessed. Results: Approximately 63.2% of students had good nutritional status. The students’ knowledge of breakfast prior to the start of the study was considered sufficient (20.3%). We found an association between the knowledge on the importance of breakfast and breakfast habits but no association was observed between nutritional status and having breakfast. Conclusion: Breakfast habits are not associated with nutritional status. Knowledge of the importance of breakfast is associated with breakfast habits.
  Adhayani Lubis , Aznan Lelo , Dina Keumala Sari and Diah S. Utami
  Background and Objectives: Cholecalciferol plays an important role in the development of brain function and neuropsychiatric disorders, especially psychological disorders. The objective of this study was to observe the differencesin25(OH)D serum levels and Brief Psychiatric Rating Scale (BPRS) scores in individuals who use amphetamine-type stimulants (ATSs) after receiving supplementation with cholecalciferol 1000 IU per day. Materials and Methods: This study had a pre and post-test design with consecutive sampling. Cholecalciferol 1000 IU per day was given to 25 ATS users (intervention/I group), while the other 25 individuals, who composed the control group (C group), did not receive any cholecalciferol supplementation for 42 days. On laboratory tests, the serum level of 25(OH)D is categorized as normal if it is within 54-90 ng mL1. Psychosis was evaluated with the BPRS questionnaire. Results: There was a significant difference in the serum level of 25(OH)D after the intervention between the groups (I group: 23.37±4.20; C group: 20.33±4.04; p = 0.012) and the increase in the serum level of 25(OH)D was greater in the I group than that of the C group. The result also showed a significant difference in BPRS score after the intervention between the groups [I group: 25(24-27); C group: 27(26-29); p<0.001]. The decrease in the BPRS score in the I group was larger than that in the C group. Conclusion: The administration of cholecalciferol 1000 IU per day increased the 25(OH)D serum level and cholecalciferol supplementation in subjects using ATSs led to a significant reduction in the BPRS score.
  Sri Lestari , Dina Keumala Sari , IstiIlmiati Fujiati , Sake Juli Martina and Nur Hidayah Nasution
  Background and Objective: Anaemia is a public health problem in developing countries. Adolescent girls are at risk of anaemia due to the increased need for iron at that age. Adolescent girls with anaemia have haemoglobin levels below the normal value limit, which is influenced by many factors, including socio-economic status and menstruation. The purpose of this study was to determine the correlation of haemoglobin levels of girls aged 11-19 years with socio-economic status and menstrual cycle duration. Materials and Methods: This was an analytic study with a cross-sectional approach. The total sample was 300 adolescent girls aged 11-19 years who were enrolled from February-July 2018. Data were collected by using the Food Frequency Questionnaire (FFQ), an anthropometric assessment and a haemoglobinometer tool. A chi-square analysis was used to find the correlation of haemoglobin levels with socio-economic status and menstrual cycle duration. Results: This study indicated that there were no significant correlations of mother’s education or tofu-tempe consumption and anaemia in adolescent girls aged 11-19 years (p>0.05); however, there were significant correlations of father’s education, income, menstrual cycle duration and meat consumption with anaemia in adolescent girls aged 11-19 years (p<0.05). Conclusion: Factors that correlated with anaemia in adolescent girls were father’s education, income, menstrual cycle duration and meat consumption. It is recommended to focus in those factors to prevent anaemia in adolescent girls.
  Juli Yosa Mega , Elrica , Dina Keumala Sari and Dewi Indah Sari Siregar
  Background and Objective: Patients with Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) infection experiences deficiency of vitamin D and abnormality of hematological parameters related to inflammatory and thrombotic activities. This study was designed to determine the relationship between changes in hematological parameters and vitamin D in HIV/AIDS infection. Materials and Methods: A cross-sectional study was conducted on 70 HIV/AIDS patients consuming Efavirenz (EFV)-based Antiretroviral Therapy (ART) for less than 6 months. Parameters including 25-hydroxy-vitamin D [25(OH)D] level and complete blood count. All parameters were measured in the Special Treatment Center (Pusat Pelayanan Khusus, Pusyansus) of the Voluntary Counseling and Testing (VCT) Clinic at Rumah Sakit Umum Pusat (RSUP) Haji Adam Malik, Medan, Indonesia. Results: There was a significant difference in terms of platelet count [mean±standard deviation: 329531.25 (79175.99) μL1 vs 282710.53 (69895.25) μL1, p = 0.011], Mean Platelet Volume/Platelet count (MPV/PLT) [Median (Interquartile Range): 2.86×105 (1.70×105-5.06×105) vs 3.27×105 (1.94×105-10.0×105), p = 0.022] and plateletcrit (PCT) [mean±standard deviation: 0.29 (0.08)% vs 0.25 (0.06)%, p = 0.018] in the group with 25(OH)D level of <21 ng mL1 compared to the group with 25(OH)D level of ≥21 ng mL1. There was a significant difference in terms of platelet count between the vitamin D sufficiency and insufficiency groups [mean±standard deviation: 300166.67 (71387.33) μL1 vs 274653.85 (69095.84) μL1, p = 0.036]. A significant difference was found in terms of platelet distribution width (PDW) between the vitamin D deficiency and insufficiency groups [mean±standard deviation: 9.02 (1.14)% vs 9.48 (1.03)%, p = 0.020]. Conclusion: Low level of vitamin D significantly correlated with platelet index in HIV/AIDS patients consuming EFV-based ART.
 
 
 
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