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Articles by Defang Chen
Total Records ( 2 ) for Defang Chen
  Ling Zhao , Kaiyu Wang , Ruqi Yang , Xun Wang , Defang Chen and Fei Shi
  To deeply explore the pharmacological activities of the Chinese truffle Tuber sinense (CT) in this study, three kinds of the crude polysaccharides from Chinese Truffle Tuber sinense (CTCP) were extracted by the method of water extracting-alcohol precipitating which include Water-soluble Polysaccharide (W-CTCP) and Alkali-soluble Polysaccharides (A-CTCPI, A-CTCPII) and then the polysaccharide content of the CTCP were determined. The antioxidant activities of the CTCPs were evaluated by reducing power, superoxide radical and hydroxyl radical free radical-scavenging assay. As the results, the polysaccharide (W-CTCP, A-CTCPI and A-CTCPII) content was 46.76, 74.05 and 57.68%, respectively. The polysaccharides all exhibited antioxidant activities in vitro and W-CTCP showed the strongest activity. It can be concluded that the polysaccharides extracted from CT should be explored as a potential natural antioxidant agent for use in functional foods or medicine.
  Ling Zhao , Kaiyu Wang , Xun Wang , Dan Huang , Juchun Lin , Defang Chen , Gang Ye and Cheng Lv
  In this study, Response Surface Methodology (RSM) was employed to optimize the extraction conditions (extraction temperature, ratio of water to raw material and extraction time) of polysaccharides from the fruiting bodies of Chinese truffle Tuber sinense. A Box-Behnken design was used for experimental design and analysis of the results to obtain the optimal processing parameters. The optimal conditions were extraction temperature 94.75°C, ratio of water to raw material 16.41:1, extraction time 2.67 h. According to analysis, extraction temperature was the most significant factor to affect the yield of polysaccharides from Chinese truffle Tuber sinense. Pharmacological experiments indicated that CTP had potent immunomodulatory effects in immunosuppression mice model. At the dose of 50, 100 and 200 mg kg-1 body weight, a significant increase (p<0.01) in phagocytosis of macrophage was observed.
 
 
 
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