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Articles by De Wu
Total Records ( 2 ) for De Wu
  Queenie C. K. Cheung , Patricia V. Turner , Cheng Song , De Wu , Hugh Y. Cai , Janet I. MacInnes and Julang Li
  Antibiotic-resistant bacteria have become a public health concern. It was suggested that one source of resistant pathogens may be food-producing animals. Alternative approaches are therefore needed to enhance the resistance of farm animals to bacterial infection. Protegrin-1 (PG-1) is a neutrophil-derived antimicrobial peptide that possesses activity against a wide range of bacteria and enveloped viruses. Here we report on the production of transgenic mice that ectopically expressed PG-1 and compare their susceptibilities to Actinobacillus suis infection with those of their wild-type (WT) littermates. Of the 126 mice that were challenged with A. suis, 87% of the transgenic mice survived, whereas 31% of their WT littermates survived. The PG-1 transgenic mice had significantly lower bacterial loads in their lungs and reduced numbers of pulmonary pathological lesions. The antimicrobial function of PG-1 was confirmed in vitro by using fibroblast cells isolated from the transgenic mice but not the WT mice. Moreover, differential blood cell counts in bronchoalveolar lavage fluid indicated greater number of neutrophils in PG-1 transgenic mice than in their WT littermates after bacterial challenge. Our data suggest that the ectopic expression of PG-1 in mice confers enhanced resistance to bacterial infection, laying the foundation for the development of livestock with improved resistance to infection.
  H. Jiang , J. Wang , L. Che , Y. Lin , Z. Fang and De Wu
  The objective of this study was to investigate the effects of different calcium sources and levels on performance and bioavailability of calcium and phosphorus in weaning piglets. A total of 90 LY (LandracexYorkshire) weaning piglets were randomly assigned to 2x8 factorial completely randomized arrangement. The two calcium sources were calcium carbonate or calcium citrate; Eight dietary calcium levels were 0.37, 0.50, 0.60, 0.70, 0.80, 0.90, 1.00 and 1.10%. Each treatment consisted of 3 replicate pens of 2 piglets. Digestibility trial was conducted from 29 to 32 day of experiment using the total collection method. No significant difference was observed on average daily gain, average daily feed intake and feed conversion rate in piglets (p>0.05) from calcium sources or interactions between calcium sources and calcium levels. There was a quadratic response of average daily gain to increasing calcium levels (p<0.05), with the optimum dietary calcium level of 0.6%. Piglets receiving dietary ranging from 0.37 to 0.80 had a higher calcium, phosphorus apparent digestibility than piglets receiving dietary ranging from 0.90 to 1.10%. Calcium citrate had significantly higher calcium apparent digestibility than calcium carbonate in piglets (p<0.05). It is concluded that calcium citrate is a good calcium source with comparable in bioavailability as calcium carbonate for weaning piglets. The piglets fed 0.6% calcium grew better, regardless of dietary calcium source.
 
 
 
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