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Articles by Daniel Yerly
Total Records ( 1 ) for Daniel Yerly
  Daniel Yerly , David Heckerman , Todd M. Allen , John V. Chisholm III , Kellie Faircloth , Caitlyn H. Linde , Nicole Frahm , Joerg Timm , Werner J. Pichler , Andreas Cerny and Christian Brander
  Hepatitis C virus (HCV) clearance has been associated with reduced viral evolution in targeted cytotoxic T-lymphocyte (CTL) epitopes, suggesting that HCV clearers may mount CTL responses with a superior ability to recognize epitope variants and prevent viral immune escape. Here, 40 HCV-infected subjects were tested with 406 10-mer peptides covering the vast majority of the sequence diversity spanning a 197-residue region of the NS3 protein. HCV clearers mounted significantly broader CTL responses of higher functional avidity and with wider variant cross-recognition capacity than nonclearers. These observations have important implications for vaccine approaches that may need to induce high-avidity responses in vivo.
 
 
 
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