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Articles by Daniel Oduro-Mensah
Total Records ( 2 ) for Daniel Oduro-Mensah
  Addai-Mensah Donkor , Daniel Oduro-Mensah , Erasmus Ani , Emmanuel Ankamah , Shadrack Nsiah , Daniel Ekow Mensah , Emmanuel Kakra Dickson and Kwadwo Asamoah Kusi
  Many herbal medicinal products contribute to the treatment of malaria in endemic areas. In Ghana, there is documented evidence of the use of several plant species in the management of both infectious and non-infectious diseases. This study sought to validate the activity of extracts from two such plants, Phyllanthus amarus and Moringa oleifera, against Plasmodium falciparum. Anti-plasmodial activities of aqueous and ethanolic extracts of M. oleifera (whole plant and twig) and P. amarus (whole plant and stem) were assessed against the 3D7 laboratory strain of P. falciparum. Extracts were evaluated in vitro at concentrations of 12.5, 25, 50, 100 μg mL–1 and the level of potency in each case was expressed as the concentration of the extract that inhibited 50% of the parasites (IC50) relative to negative controls (100% parasitaemia). Artesunate was used as a positive standard in all assays. All extracts showed significant inhibition of parasite growth, with (IC0) less than 50 μg mL–1, except the aqueous extract of the whole plant of P. amarus which showed a relatively high IC50 of 115.43 μg mL–1. Interestingly, increasing concentration of ethanolic extract of combined twig and leaves of Moringa oleifera reduced inhibition of the parasite growth while a decreasing extract concentration resulted in increased parasite inhibition. The extracts of M. oleifera and P. amarus demonstrated potential anti-plasmodial activity which can be explored in malaria therapy. It is of interest to identify, isolate and characterize the active anti-plasmodial bioactive compounds from the plants.
  Addai-Mensah Donkor , Daniel Oduro-Mensah and M. Konona-Ang Patience
  Background: In rural settings, some medicinal plant extracts serve as alternative agents for wound treatment. Topical application of such extracts would be greatly enhanced if formulations such as ointment-based preparations were available. Methodology: This study sought to investigate the antibacterial activity of polyethylene glycol ointment formulations of crude extracts of Cleome viscosa, Tamarindus indica and Euphorbia hirta against Pseudomonas aeruginosa and Escherichia coli. Antibacterial activities were studied at concentrations of 25, 50, 100 and 200 μg mL–1 for the test extracts and 25, 50, 100 and 200 μg g–1 for the polyethylene glycol formulations. Results: Generally, the crude extracts as well as their formulations showed increasing levels of inhibition with increasing concentrations. Polyethylene glycol formulations of Euphobia hirta and Cleome viscosa crude extracts exhibited significant potencies against growth of Pseudomonas aeruginosa and Escherichia coli. Conclusion: Both Euphobia hirta and Cleome viscosa crude extract-polyethylene glycol ointments have therefore emerged as potentially effective formulations against Escherichia coli and P. aeruginosa wound infections.
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