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Articles by D.S. Rajput
Total Records ( 2 ) for D.S. Rajput
  Harshita Patel and D.S. Rajput
  The fast technological era facilitated with various computational devices leads to the exponential growth of data, need proper treatment; well known data warehousing and data mining terms are directly imply to produce informational processing of these huge datasets. Apart from storing and updating routine data, data mining provide the extraction of valuable knowledge, actually needed for decision making. From scientific data to organizational details, sports to banking data or library to security concerns every field dealing with large amount of data require data mining tools to dig strategic information for their respective requirements. In this study, researchers will study some data mining application areas.
  D.S. Rajput , Amit Alexander , Vishal Jain , T.K. Giri , D.K. Tripathi and Ajazuddin
  The oral delivery of hydrophobic drugs faces a major challenge because of the low aqueous solubility of such compounds. Approximately, 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system because of their low bioavailability. The availability of the drug for absorption can be enhanced by presentation of the drug as a solubilizer within a colloidal dispersion. Self-emulsifying Drug Delivery Systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds. The principal characteristic of these systems is their ability to form fine oil-in-water (o/w) emulsions or microemulsions upon mild agitation following dilution by an aqueous phase through the gastrointestinal tract for lipophilic drugs, which display dissolution rate-limited absorption. SEDDS may be a promising strategy to improve the rate and extent of oral absorption. This article gives an overview of the recent advances in the study of SEDDS and improvement of pharmacokinetic parameters of bioactives through SEDDS.
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