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Articles by D.D. Bandawane
Total Records ( 3 ) for D.D. Bandawane
  A.A. Mali , D.D. Bandawane and M.G. Hivrale
  Background: Cassia auriculata L. is highly valued in Indian medicines for management of painful inflammation and diabetes. The objective of this study was to evaluate the anti-inflammatory and analgesic potential of methanolic extract of C. auriculate leaves (MECA). Materials and Methods: The MECA (300 and 600 mg kg-1) was subjected to anti-inflammatory, analgesic activity using carrageenan induced rat paw edema, cotton pellet induced granulomatous chronic inflammation, hot plate method and tail immersion method. The antioxidant potential of MECA was determined by using 1,1-diphenyl-2- picrylhydrazyl (DPPH) radical scavenging, nitric oxide radical scavenging activity and reducing power assay. In addition to this the ulcerogenicity of the extract was tested using ethanol induced ulcer model. Results: Results showed that MECA significantly (p<0.05 and p<0.01) inhibited inflammation induced by carrageenan and cotton pellet implants. There was significant (p<0.05 and p<0.01) increase in latency periods in Eddy’s hot plate and tail immersion induced pain. Similarly, MECA at 100 μg mL-1 exhibited significant (p<0.01) reducing power, DPPH free radical scavenging and nitric oxide radical scavenging activity. Conclusion: The results obtained indicate that MECA has dose dependant anti-inflammatory activity, central analgesic activity and lack ulcerogenicity. These activities of MECA are attributed to its antioxidant mechanism and presence of tannins and flavonoids which themselves are responsible for antioxidant potential.
  D.D. Bandawane , K.H. Bibave , A.V. Jaydeokar , U.S. Patil and M.G. Hivrale
  Background: Holarrhena antidysenterica L. (family Apocynaceae) is traditionally used in Ayurvedic system of Indian medicine for the treatment of diabetes mellitus. Therefore, the present work was undertaken to evaluate the antidiabetic and antihyperlipidemic effects of methanolic extract of Holarrhena antidysenterica Bark (MEHA) in alloxan induced diabetes mellitus and to focus on its possible mechanism. Materials and methods: Wistar albino rats (150-220 g) of either sex were used for the study. Diabetes was induced in rats by injecting alloxan (150 mg kg-1) intraperitoneally. Group I served as normoglycemic rats. Group II served as diabetic control. Group III and IV served as diabetic rats treated with 200 and 400 mg kg-1 of MEHA, respectively. Group V served as diabetic rats treated with oral hypoglycaemic agent, glibenclamide (4 mg kg-1 p.o.). Group VI and VII served as normoglycemic rats treated with 200 and 400 mg kg-1 of MEHA. All the treatments were given for 28 days. At the end of study, on 28th day, overnight fasted rats were sacrificed and blood was collected to determine fasting blood glucose, triglycerides, total cholesterol, high density lipoprotein, low density lipoprotein, very low density lipoprotein, total protein, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. To study in vivo antioxidant activity, liver tissues of different groups were homogenized to determine maloaldehyde (MDA), catalase (CAT), Super Oxide Dismutase (SOD) and reduced glutathione (GSH). Additional parameters were estimated to focus on mechanism of action were liver glycogen content and glucose uptake from hemidiaphragms. Results: Diabetic rats treated with MEHA in doses of 200 and 400 mg kg-1 significantly (p<0.01) reduced fasting blood glucose and normalized the lipid profile in comparison to diabetic control group. There was dose dependent decrease observed in transaminases, BUN and MDA whereas there was significant (p<0.01) improvement in total proteins, liver catalase, SOD and GSH in MEHA treated groups. MEHA (200 and 400 mg kg-1) treated diabetic rats showed significant improvement in liver glycogen and glucose uptake by rat diaphragm. Improvement in histopathology of pancreas of MEHA treated rats confirmed its protective role in alloxan induced diabetes. Conclusion: It can be concluded that MEHA possesses antihyperglycemic activity with antihyperlipidemic and antioxidant potential which may prove beneficial in cardiovascular complications associated with diabetes mellitus.
  N.K. Mhetre , D.D. Bandawane and A.N. Patel
  Background: Cassia auriculata Linn. (Caesalpiniaceae) is a potential folklore medicinal plant traditionally used for the treatment of diabetes. The objective of the present study was to evaluate the antihyperglycemic activity of hydroalcoholic extract of aerial parts of Cassia auriculata L. (HACA) in streptozotocin induced diabetes in rats, to focus on its possible mode of action and to identify the possible phytoconstituents responsible for the proposed activity. Materials and Methods: Experimental diabetes was induced in Wistar rats by single intraperitoneal injection of streptozotocin (65 mg kg-1). Diabetic rats were divided in six groups (n = 6) and treated with variable doses of HACA (100, 200 and 400 mg kg-1) for 4 weeks. At the end of study, blood glucose, plasma insulin, glycosylated hemoglobin and lipid profile were determined. In addition, glycogen content of liver, skeletal muscle and in vivo intestinal glucose absorption were also evaluated. The activities of liver and kidney functional markers were measured. HACA was also subjected to in vitro α-amylase, α-glucosidase inhibition assay along with qualitative and quantitative phytochemical analysis. Results: Daily oral administration of HACA for 28 days to diabetic rats produced significant decrease in fasting blood glucose, glycosylated hemoglobin, intestinal glucose absorption along with the corrections of diabetic dyslipidemia compared to untreated diabetic rats. Further, significant improvement was observed in glycogen content of liver and skeletal muscle in HACA treated diabetic rats. There was significant decrease in the activities of liver and renal functional markers in diabetic treated rats compared to untreated diabetic rats indicating the protective role of HACA against liver and kidney damage and its non-toxic property. HACA showed prominent inhibitory effect against α-amylase and α-glucosidase enzyme in the in vitro tests. Phytochemical analysis of HACA revealed the presence of gallic acid and quercetin in HACA. Conclusion: The results of our study demonstrate antihyperglycemic potential of aerial parts of Cassia auriculata L. justifying its use in the indigenous system of medicine. Hence this plant may be considered as one of the potential sources for the isolation of new oral antihypoglycemic agent(s).
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