Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by D. Wang
Total Records ( 7 ) for D. Wang
  L. Luo , W. Zhou and D. Wang
  The interaction of river flow, tidal mixing, basin morphology and wind produces a different type of river plume in the Pearl River Estuary. In this paper, a three-dimensional numerical model has been used to study the response of the river plume to different forcings in the Pearl River Estuary. The results indicate that river discharge determines the font size of river plume, while wind greatly affects its shape. Tidal current can restrict diluted water spreading seaward, but contributes little to the net transport of low salinity water. The flushing time can increase by 2 times when considering the Coriolis force, which delays the diluted water flowing out of the flushing area. Southwest winds can greatly decrease the flushing time, while northeast winds can increase it. This rule can also be valid when considering tides.
  X. Zhou , D. Wang , D. Hu and Q. Lin
  In this study, we consider the design of a radio resource allocation technique for an Orthogonal Frequency Division Multiple Access (OFDMA) based Multiple Input Multiple Output (MIMO) multihop network. To avoid the inter-hop interference, the half-duplex orthogonal relay channel construction method and related multihop transmission scheme are designed. Over Nakagami-m fading channels, we propose a low-complexity resource allocation algorithm using Meijer G-function. And, the long term fairness performance is also investigated. Simulation shows that the proposed analytical algorithm is efficient and with good accuracy to Monte Carlo results. And, simulations also demonstrate that the spatial diversity gain offered by relay antenna array can effectively balance the tradeoff between the fairness performance and the system throughput.
  P Liu , W Chen , H Zhu , B Liu , S Song , W Shen , F Wang , S Tucker , B Zhong and D. Wang
  Objective

The purpose of this study was to specifically investigate the clinicopathological role of expression of vascular endothelial growth factor-C (VEGF-C) as well as the correlation with clinical outcomes in esophageal squamous cell carcinomas (ESCCs).

Methods

Seventy-three patients with ESCC resected in our institute were included in this study. Formalin-fixed paraffin-embedded specimens were stained for VEGF-C and the correlation between the staining, its clinicopathological parameters and its prognostic power were analyzed statistically.

Results

Of the 73 ESCC patients studied, 39 cases (53.4%) were strongly positive for VEGF-C. Six cases (8.2%) were negative and 28 cases (38.4%) revealed unclear weak reactions. All 34 cases were included in the negative group (46.6%). VEGF-C expression correlated with histological grade (P = 0.005), depth of tumor invasion (pT) (P = 0.021), lymph node metastasis (pN) (P = 0.002) and lymphatic invasion (P = 0.008). The median overall survival of 39 patients who had positive staining for tumor cell VEGF-C and 34 patients who had negative staining were 10.4 months (95% CI, 6.9–13.9 months) and 28.5 months (95% CI, 12.6–44.4 months), respectively (P = 0.003). In univariate analysis by log-rank test, histological grade, pN, stage, lymphatic invasion and VEGF-C were significant prognostic factors (P = 0.047, 0.007, 0.018, 0.002 and 0.003, respectively.). In multivariate analysis, high VEGF-C expression (P = 0.0451) maintained its independent prognostic influence on overall survival, as well as pN status (P = 0.0029).

Conclusions

Expression of VEGF-C is related to histological grade, pT, pN and lymphatic invasion, and is a prognostic indicator for ESCC.

  R Zhao , J Zhu , X Ji , J Cai , F Wan , Q Li , B Zhong , S Tucker and D. Wang
  Objective

To assess the resectability rate of patients with initially unresectable liver-only metastases from colorectal cancer (CRC) after treatment with irinotecan/capecitabine.

Methods

Patients received irinotecan (240 mg/m2) as a 30 min intravenous infusion on day 1 and capecitabine (1000 mg/m2) orally bid for 14 days beginning on day 2. Treatment was repeated every 3 weeks. The protocol encouraged two to four cycles of irinotecan/capecitabine after recovery from surgery.

Results

Between May 2004 and February 2007, 48 patients entered in the study. Forty-seven (97.9%) of the 48 patients were assessable for response. The overall response rate before surgery was 56.3% (95% CI, 42.3–70.3%) in the treated population, including 2 non-confirmed complete response (CR), 18 partial responses (PR) and 7 non-confirmed PR. Twenty-three (47.9%) of 29 patients with tumor shrinkage proceeded to surgical intervention. Twenty of the 23 patients had a complete resection (S-CR). With a median follow-up time of 32 months (range, 24–38 months), the overall median time to progression and overall survival for all patients were 16.7 months (95% CI, 10.0–23.4 months) and 27.5 months (95% CI, 23.6–31.4 months) for all patients. The 1- 2- and 3-year overall survival estimates were 79.2% (95% CI, 67.7–90.7%), 60.4% (95% CI, 46.6–74.3%) and 29.2% (95% CI, 16.3–42.0%), respectively. Grade 3 diarrhea occurred in eight (17.0%) patients. The most common Grade 3/4 hematological adverse event was neutropenia in 8.5% of the patients. There were no treatment-related deaths during this study.

Conclusions

Irinotecan/capecitabine appears to be a safe and very effective regimen in selected patients with unresectable liver metastases from CRC, but who are treated with a curative intent.

  J Zheng , G Wang , G. Y Yang , D Wang , X Luo , C Chen , Z Zhang , Q Li , W Xu , Z Li and D. Wang
  Objective

This Phase II study was conducted to evaluate the activity and feasibility of a regimen of nedaplatin and 5-fluorouracil as induction chemotherapy, followed by intensity-modulated radiotherapy concurrent with chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma.

Methods

Patients received neoadjuvant chemotherapy comprised two cycles of 5-fluorouracil at 700 mg/m2/day administered on days 1–4 as continuous intravenous infusion and nedaplatin (100 mg/m2 administered i.v. over 2 h) given after the administration of 5-fluorouracil on day 1, repeated every 3 weeks, followed by intensity-modulated radiotherapy concurrent with nedaplatin. During intensity-modulated radiotherapy, nedaplatin was administered at a dose of 100 mg/m2 intravenous infusion on days 1, 22 and 43, given ~60 min before radiation.

Results

Fifty-nine (95.8%) of the 60 patients were assessable for response. Thirty-eight cases of complete response and 14 cases of partial response were confirmed after completion of chemoradiation, with the objective response rate of 86.7% (95% CI, 78.1–95.3%). The median follow-up period was 48 months (range, 30–62 months). The 3-year progression-free survival and overall survival were 75.0% (95% CI, 63.0–87.0%) and 85.5% (95% CI, 75.9–95.1%). No patient showed Grade 3 or higher renal dysfunction. The most commonly observed late effect was xerostomia, but the severity diminished over time, and the detectable xerostomia at 24 months was 10.2%. There were no treatment-related deaths during this study.

Conclusions

Neoadjuvant chemotherapy with nedaplatin and 5-fluorouracil followed by concomitant nedaplatin and intensity-modulated radiotherapy is an effective and safe treatment for Southern China patients affected by locoregionally advanced nasopharyngeal carcinoma.

  J. Chen , H.B. Zhu , D. Wang , F.Q. Wang , H.S. Hao , W.H. Du and X.M. Zhao
  The objective of this study was to estimate the genetic parameters for growth traits in a cross between Piedmontese and Nanyang cattle. Data from the pure Italian Piedmontese and Chinese Nanyang breeds as well as from crosses between these two breeds were used to estimate genetic parameters and variance. Data were extracted from a base data set (49,646 growth records of 9,003 animals from 13 herds). The data were analyzed using the multiple-trait Restricted Maximum Likelihood (REML) Method to estimate the variance and the genetic parameters. The multiple-trait analysis included weights at birth, 6, 12, 18, 24 months and maturity. Weight heritability ranged from 0.34±0.01-0.54±0.03; the heritabilities at 24 months and at maturity were higher than at all other time points. Results indicated that growth traits were good traits for selection and cattle genetic evaluation. The estimates obtained in this study will be used in the breeding value estimation for national genetic evaluations of the Chinese crossbreed population between Piedmontese beef cattle and Nanyang Yellow cattle.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility