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Articles by D. Liu
Total Records ( 2 ) for D. Liu
  X. -Q. Yang , L. -J. Guo , C. -Y. Zhai , H. Yu , H. Liu and D. Liu
  This study was designed to clone the porcine calpain 7 gene, CAPN7, to characterize its tissue expression, and to investigate its genetic variation. The cDNA sequence that contains a 2442 bp open reading frame encoding 813 amino acids was obtained by reverse transcription-polymerase chain reaction and rapid amplification of cDNA ends methods based on in slico cloning and homologous cloning, and five introns were identified. Quantitative real-time PCR showed that CAPN7 was ubiquitously expressed in all tissues examined, and the mRNA level in muscles was low at 1-7-days-old and high from 90 to 270-days-old. In addition, two single nucleotide polymorphisms in coding sequence were identified and the polymerase chain reaction-restriction fragment length polymorphism methods were established to detect the polymorphisms. At each site, the distribution of three genotypes is significantly different (P<0.01) in Yorkshire, Duroc, Wild boar, and Min pigs.
  H Wang , Y Wang , L Sun and D. Liu
 

The 3' untranslated region (3' UTR) of eukaryotic mRNA is an important regulation element that affects not only mRNA translation, but also cell growth. We had found that the 3' UTR of CCAAT-enhancer-binding protein β (C/EBPβ) mRNA had tumor suppression activity. Herein, we reported that deletion of two short sequences at both termini of the C/EBPβ 3' UTR reduced the tumor suppression activity of this 3' UTR, as demonstrated by reduced cell growth, colony formation ability, and tumorigenicity in nude mice. It is noteworthy that the only deletion of a single such sequence was enough for the reduction of tumor suppression effect, and the reducing effect of deletion of the sequence near 3' terminus was stronger. Therefore, specific short sequences in the C/EBPβ 3' UTR are crucial for the tumor suppression activity of C/EBPβ.

 
 
 
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